A Novel Control of Human Keratin Expression: Cannabinoid Receptor 1-Mediated Signaling Down-Regulates the Expression of Keratins K6 and K16 in Human Keratinocytes In Vitro and In Situ

    February 2013 in “ PeerJ ”
    Yuval Ramot, Koji Sugawara, Nóra Zákány … Ralf Paus
    Studysummary This study found that CB1 activation by a specific agonist led to decreased expression of keratins K6 and K16 in human skin and inhibited keratinocyte proliferation, suggesting potential for cannabinoid receptors in psoriasis management.
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    Research cited in this study 8

    1. Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin Journal of Allergy and Clinical Immunology · 2012
    2. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011
    3. Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro British Journal of Dermatology · 2010
    4. Thyroid-Stimulating Hormone: A Novel, Locally Produced Modulator of Human Epidermal Functions, Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones Endocrinology · 2010
    5. Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ The FASEB Journal · 2010
    6. The Melanocyte-Keratin Mystery Revisited: Neither Normal Human Epidermal Nor Hair Follicle Melanocytes Express Keratin 16 or Keratin 6 In Situ British Journal of Dermatology · 2009
    7. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    8. Keratins of the Human Hair Follicle International review of cytology · 2005