A Novel Control of Human Keratin Expression: Cannabinoid Receptor 1-Mediated Signaling Down-Regulates the Expression of Keratins K6 and K16 in Human Keratinocytes In Vitro and In Situ

    February 2013 in “ PeerJ ”
    Yuval Ramot, Koji Sugawara, Nóra Zákány, Balázs István Tóth, Tamás Bı́ró, Ralf Paus
    TLDR Activating cannabinoid receptor 1 reduces certain keratin levels, potentially aiding psoriasis treatment.
    The study found that cannabinoid receptor 1 (CB1) signaling, through the agonist ACEA, down-regulated the expression of keratins K6 and K16 in human keratinocytes, both in vitro and in situ, and reduced keratinocyte proliferation. This suggested that CB1 activation could be a potential therapeutic target for managing hyperproliferative skin conditions like psoriasis. The research involved skin samples from 4 individuals and used methods such as immunohistochemistry to assess changes in keratin expression, indicating that CB1 agonists might be explored as treatments for skin conditions with abnormal keratin expression and proliferation.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 7 results

      community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

      in Research/Science  4 upvotes 1 year ago
      Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

      community My microneedling journey (no min, fin, etc)

      in Microneedling  210 upvotes 1 year ago
      The user experienced positive hair growth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.

      community About the CBD regrowth study : just a few remarks

      in Research/Science  165 upvotes 4 years ago
      CBD in an emu and lanolin oil preparation showed a 100% increase in hair growth, but the effectiveness may partly come from the oils. Users discussed proper CBD dosage, preparation methods, and skepticism about the study's quality.

      community Marijuana and hair loss?

       6 upvotes 9 years ago
      The conversation discusses the potential impact of marijuana on hair loss, with some users suggesting it may worsen hair loss due to hormonal changes, while others believe it might alter perception rather than cause actual thinning. The original poster uses Propecia (finasteride) and Rogaine (minoxidil) for treatment and is considering quitting marijuana to see if it affects hair health.

      community 11mth daily 0.5mg oral finasteride

      in Finasteride/Dutasteride  835 upvotes 1 year ago
      The user experienced significant hair regrowth with 0.5mg oral finasteride daily, despite a minoxidil allergy, and reported no side effects. They also used a keto shampoo and were satisfied with the results.

    Similar Research

    5 / 271 results