Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System

March 2019 in “ Molecules/Molecules online/Molecules annual ”

Kinga Fanni Tóth, Dorottya Ádám, Tamás Bı́ró, Attila Oláh

cannabinoid signaling C(ut)annabinoid system hair growth alopecia CB1 receptor CB2 receptor skin homeostasis immune responses inflammation hair follicle biology hair loss disorders acne psoriasis atopic dermatitis systemic sclerosis fibrosis cannabinoids hair loss skin conditions

Studysummary This review discusses the role of the endocannabinoid system in skin health and disease, highlighting its potential for future research and applications, but reports no new experimental results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reviewed the therapeutic potential of cannabinoid signaling in the skin, referred to as the "C(ut)annabinoid" system, highlighting its influence on various skin conditions such as hair growth, alopecia, inflammation, and skin cancers. It discussed how cannabinoids interact with receptors like CB1 and CB2, affecting skin homeostasis, immune responses, and inflammation. Evidence suggested that cannabinoids could modulate hair follicle biology, offering potential treatments for hair loss disorders. Additionally, cannabinoids showed promise in treating conditions like acne, psoriasis, atopic dermatitis, and systemic sclerosis by reducing inflammation and fibrosis. The document emphasized the need for further research to fully understand the mechanisms and therapeutic applications of cannabinoids in dermatology.

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