Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System

The document reviewed the therapeutic potential of cannabinoid signaling in the skin, referred to as the "C(ut)annabinoid" system, highlighting its influence on various skin conditions such as hair growth, alopecia, inflammation, and skin cancers. It discussed how cannabinoids interact with receptors like CB1 and CB2, affecting skin homeostasis, immune responses, and inflammation. Evidence suggested that cannabinoids could modulate hair follicle biology, offering potential treatments for hair loss disorders. Additionally, cannabinoids showed promise in treating conditions like acne, psoriasis, atopic dermatitis, and systemic sclerosis by reducing inflammation and fibrosis. The document emphasized the need for further research to fully understand the mechanisms and therapeutic applications of cannabinoids in dermatology.