TLDR TRPV4 slows hair growth by affecting hair follicle cells.
The study found that the TRPV4 ion channel was expressed in the outer root sheath of human hair follicles and its activation inhibited hair growth in vitro. Activation of TRPV4 by the agonist GSK1016790A resulted in decreased hair shaft elongation, increased the catagen phase, and reduced cell proliferation while increasing apoptosis in hair follicle cells. These effects were due to calcium influx and could be blocked by a TRPV4 antagonist. The research suggested that TRPV4, similar to TRPV1 and TRPV3, played a role in hair follicle cycling and could be a potential target for further research on hair growth and related disorders.
105 citations
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May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” Activating TRPV3 stops human hair growth.
174 citations
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April 2005 in “The American journal of pathology (Print)” Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.
1 citations
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January 2024 in “International journal of molecular sciences” TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.
4 citations
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June 2020 in “British Journal of Pharmacology” Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.
May 2025 in “Experimental Dermatology” Triphenylphosphine oxide can increase oil production and reduce inflammation in skin cells without affecting TRPM5.
3 citations
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December 2022 in “Cells” Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.
January 2023 in “Theranostics” Mechanical force is important for the first contact between skin cells and hair growth in mini-organs.
