The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner

May 2025 in “ Experimental Dermatology ”

Dorottya Ádám, József Arany, Kinga Tóth, on behalf of the Coll Cancer Richard Peto, T. Nyitrai, Balázs István Tóth, Szilárd Póliska, Christos C. Zouboulis, Attila Oláh

TRPM5 triphenylphosphine oxide sebaceous lipogenesis human sebocytes Akt pathway EGFR pathway diacylglycerol O-acyltransferase-2 interleukin-6 IL-6 IL-8 pro-inflammatory cytokines TPPO DGAT-2

TLDR Triphenylphosphine oxide can increase oil production and reduce inflammation in skin cells without affecting TRPM5.

The study explores the effects of the TRPM5 antagonist triphenylphosphine oxide (TPPO) on human sebocytes, finding that TPPO enhances sebaceous lipogenesis and modulates immune responses independently of TRPM5. TPPO increases lipid production and alters cytokine expression, notably increasing IL-6 and decreasing IL-8, through pathways involving Akt, EGFR, and p38α MAPK. These changes suggest potential therapeutic benefits for inflammatory skin conditions like atopic dermatitis or psoriasis, without adverse effects on sebaceous glands. The study confirms that TRPM5 is not functionally active in sebocytes, and TPPO's effects are mediated through multiple signaling pathways, highlighting its potential in acne treatment strategies.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations

21 citations , November 2022 in “Frontiers in immunology”

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

research Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses

26 citations , August 2018 in “Journal of Investigative Dermatology”

Activating TRPV3 reduces skin oil production and increases inflammation, potentially causing dry skin issues.

research Marked Reduction of the Number and Individual Volume of Sebaceous Glands in Psoriatic Lesions

10 citations , January 2016 in “Dermatology”

Psoriasis lesions have fewer and smaller oil glands, which might affect the condition's development.

Related Community Posts Join

6 / 7 results

community Completely obliterated my diffuse thinning without Finasteride w/ pictures

in Journals / Progress Pictures 167 upvotes 9 months ago

The user improved diffuse thinning without finasteride by using minoxidil foam, cold showers, gentle hair drying, 2% ketoconazole, sulfate-free tea tree oil shampoo, dermastamping, and supplements like Omega-3, Vitamin-D, Biotin, Keratin, Collagen, B3, Zinc, and Magnesium. The regimen was followed for about six months under dermatologist guidance.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 11 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 9 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 9 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community My microneedling journey (no min, fin, etc)

in Microneedling 210 upvotes 11 months ago

The user experienced positive hair growth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.

community progress has been insane, been having a bad shed for about a month or 2, can anyone explain?

in Progress Pictures 678 upvotes 1 year ago

User experienced significant hair regrowth using minoxidil and dutasteride, along with microneedling, vitamins, and massages. Despite recent shedding, they hope it's a synchronized hair cycle and plan to continue the treatment.

Similar Research

5 / 90 results

A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels

research A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels

5 citations , January 2018

The conclusion is that a new test was created to find substances that affect specific ion channels, and it works well for drug discovery.

Dental Cell Type Atlas Reveals Stem and Differentiated Cell Types in Mouse and Human Teeth