TNC+ Fibroblasts Involved in Skin Inflammation via Neuro-Immune Interactions with T Cells

This study investigates the role of TNC+ fibroblasts in skin inflammation through neuro-immune interactions, particularly focusing on their involvement in over 20 skin diseases. Using various RNA sequencing data and bioinformatics tools, the researchers identified that TNC+ fibroblasts are significantly associated with inflammatory genes and immune cell infiltration, especially interacting with T cells via ligand-receptor pairs like collagens-CD44. Key transcription factors such as EPAS1, HIF1A, and STAT1 were identified as intermediates in these processes. The findings highlight the crucial role of TNC+ fibroblasts in skin inflammation and provide insights into their molecular mechanisms across different skin diseases.