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GlossaryHypoxia-Inducible Factor 1-alpha (HIF1A)

protein that helps cells adapt to low oxygen levels

Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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Transgenic Erythropoietin Overexpression Inhibits Dermal Fat Formation and HIF1a in the Skin and Causes Telogen Effluvium in Mouse Pups During the First Hair Cycle

research Transgenic Erythropoietin Overexpression Inhibits Dermal Fat Formation and HIF1a in the Skin and Causes Telogen Effluvium in Mouse Pups During the First Hair Cycle

June 2024 in “Diabetes”

Erythropoietin overexpression disrupts hair growth and fat formation in mice.

research HIF1A Stabilization in the Human Hair Follicle Promotes Glycolysis

April 2018 in “Journal of Investigative Dermatology”

Stabilizing HIF1A in hair follicles increases glycolysis, which may help reduce oxidative stress and support hair growth.

research CD201+ Fascia Progenitors Choreograph Injury Repair

5 citations, September 2022 in “Research Square (Research Square)”

CD201+ fascia progenitors are essential for wound healing and could be targeted for treating skin conditions.

research Defining the Transcriptional Signature of Esophageal-to-Skin Lineage Conversion

3 citations, February 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Adult esophageal cells can start to become like skin cells, with a key pathway influencing this change.

research Network Pharmacology Reveals Curcuma Aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia

July 2024 in “Biology”

Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.

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community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community Guys be like: 1 month on minoxidil and 1 month on finasteride

in Satire 2 years ago

This conversation is a humorous discussion about the effects of Minoxidil and Finasteride on hair growth, with some users speculating that it may have turned the poster into a "scientific horror story".

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 7 months ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community 48 Days Fin, Min, and Derm Part 2

in Progress Pictures 264 upvotes 1 year ago

The user discussed their positive experience with hair loss treatments Finasteride, Minoxidil, and Dermarolling, showing significant progress in 48 days. Other users expressed interest in trying these treatments, asked about side effects, and one noted that they've observed good results in black people.