Matrisomal Components Involved in Regenerative Wound Healing in Axolotl and Acomys: Implications for Biomaterial Development

January 2023 in “ Biomaterials Science ”

Nancy Avila-Martinez, Merel Gansevoort, J. M. A. Verbakel, Haarshaadri Jayaprakash, Inês M. Araújo, Marta Vitorino, Gustavo Tiscornia, Toin H. Van Kuppevelt, Willeke F. Daamen

matrisome glycosaminoglycan GAG matrix metalloproteinase 3 matrix metalloproteinase 13 tissue inhibitor of metallopeptidase 1 Timp1 extracellular matrix ECM

TLDR Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.

The review paper investigates the role of matrisome components in regenerative wound healing in axolotl and Acomys, two species known for their regenerative abilities. The study compared the wound healing responses and matrisome gene expression patterns in these species, focusing on glycosaminoglycan (GAG) related genes. The aim was to identify matrisome genes that are upregulated during regeneration, which could be potential candidates for inclusion in pro-regenerative biomaterials. The analysis revealed several genes that were consistently upregulated, suggesting their possible involvement in regenerative processes. The study also highlighted the importance of matrix remodeling in wound healing, with matrix metalloproteinase 3, matrix metalloproteinase 13, and tissue inhibitor of metallopeptidase 1 (Timp1) being upregulated. The research concluded that a regenerative biomaterial should focus on re-establishing the normal ECM architecture and organization for effective wound healing. The ultimate goal is to apply this knowledge to improve wound healing and achieve regeneration in humans.

View this study on pubs.rsc.org →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice

1 citations, April 2023 in “Science Advances”

High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.

research Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice

22 citations, May 2021 in “Nature Communications”

Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

research Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys Cahirinus and Scarring Mus Musculus

13 citations, January 2020 in “Scientific Reports”

The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.

research Comparative Transcriptomic Analysis of Dermal Wound Healing Reveals De Novo Skeletal Muscle Regeneration in Acomys Cahirinus

24 citations, May 2019 in “PLOS ONE”

The African spiny mouse can fully regenerate its muscle without scarring, unlike the common house mouse.

research Insights into the Regeneration of Skin from Acomys, the Spiny Mouse

19 citations, November 2018 in “Experimental Dermatology”

The spiny mouse can regenerate its skin without scarring, which could help us learn how to heal human skin better.

research The Blastema and Epimorphic Regeneration in Mammals

85 citations, December 2017 in “Developmental Biology”

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

research Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)

418 citations, September 2012 in “Nature”

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

Similar Research

5 / 47 results

research In Vitro Strategies for Mimicking Dynamic Cell–ECM Reciprocity in 3D Culture Models

June 2023 in “Frontiers in Bioengineering and Biotechnology”

The conclusion is that accurately replicating the complexity of the extracellular matrix in the lab is crucial for creating realistic human tissue models.

research Modulation of Macrophage Functions by ECM-Inspired Wound Dressings – A Promising Therapeutic Approach for Chronic Wounds

9 citations, August 2021 in “Biological Chemistry”

ECM-inspired wound dressings can help heal chronic wounds by controlling macrophage activity.

research Dermal Niche Signaling and Epidermal Stem Cells

January 2019 in “Advances in stem cells and their niches”

Skin health and repair depend on the signals between skin stem cells and their surrounding cells.

research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

2 citations, September 2023 in “International journal of molecular sciences”

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

research Adipose-Derived Stem Cells in Skin Diseases, Wound Healing, and Skin Defects: A Review

2 citations, September 2022 in “Cytotherapy”

Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.