Matrisomal Components Involved in Regenerative Wound Healing in Axolotl and Acomys: Implications for Biomaterial Development
January 2023
in “
Biomaterials Science
”
TLDR Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.
The review paper investigates the role of matrisome components in regenerative wound healing in axolotl and Acomys, two species known for their regenerative abilities. The study compared the wound healing responses and matrisome gene expression patterns in these species, focusing on glycosaminoglycan (GAG) related genes. The aim was to identify matrisome genes that are upregulated during regeneration, which could be potential candidates for inclusion in pro-regenerative biomaterials. The analysis revealed several genes that were consistently upregulated, suggesting their possible involvement in regenerative processes. The study also highlighted the importance of matrix remodeling in wound healing, with matrix metalloproteinase 3, matrix metalloproteinase 13, and tissue inhibitor of metallopeptidase 1 (Timp1) being upregulated. The research concluded that a regenerative biomaterial should focus on re-establishing the normal ECM architecture and organization for effective wound healing. The ultimate goal is to apply this knowledge to improve wound healing and achieve regeneration in humans.
