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research Matrisomal Components Involved in Regenerative Wound Healing in Axolotl and Acomys: Implications for Biomaterial Development

January 2023 in “Biomaterials Science”

Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.

research An ERK-Dependent Molecular Switch Antagonizes Fibrosis And Promotes Regeneration In Spiny Mice (Acomys)

June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

A specific molecular switch, driven by MAPK/ERK signaling, helps spiny mice heal wounds by regenerating skin instead of forming scars.

research Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions

35 citations , May 2021 in “Nature communications”

The skin's basement membrane has specialized structures and molecules for different tissue interactions, important for hair growth and attachment.

research Strength And Tenderness: Fibronectin Joins Hair Follicle Stem Cell Niche

August 2025 in “Journal of Investigative Dermatology”

Fibronectin is essential for hair follicle regeneration and may help rejuvenate aged skin.

research Enter The Matrix: Fibroblast-Immune Cell Interactions Shape Extracellular Matrix Deposition In Health And Disease

6 citations , December 2024 in “F1000Research”

Fibroblast and immune cell interactions affect tissue repair and fibrosis.

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community Verteporfin and Microneedling

nkrata in Treatments 1 year ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.