Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys Cahirinus and Scarring Mus Musculus
January 2020
in “
Scientific Reports
”
scar-free skin regeneration Acomys cahirinus Mus musculus protein degradation protein synthesis cell cycle survival mechanisms ubiquitin/proteasome pathway Wnt pathway cell migration inflammatory response fibrotic extracellular matrix arginase macrophages proteomic differences fibrotic responses wound healing in-gel tryptic digestion LC-MS/MS analysis Western blot analysis scar-free healing African spiny mouse house mouse protein breakdown protein creation cell division cell survival ubiquitin pathway Wnt signaling cell movement inflammation fibrosis arginase enzyme immune cells protein differences scar formation healing process tryptic digestion mass spectrometry Western blot
Studysummary This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.
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