Search

for
Search:

Research

5 / 909 results

Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing Beta-Catenin

research Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin

3 citations , August 2013 in “Stem cells”

This study found that topical application of partial proteasomal inhibitors accelerates hair growth by stabilizing β-catenin and disrupting the hair cycle's normal balance of activation and quiescence.

research Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer

18 citations , April 2011 in “International Journal of Molecular Medicine”

This study found that dihydrotestosterone (DHT) regulates the degradation of p27 in MCF-7 breast cancer and OVCAR-3 ovarian cancer cells, involving SKP2 as a key factor.

research Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus

13 citations , January 2020 in “Scientific Reports”

This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.

research Analysis of Dermal Papilla Cell Interactome Using STRING Database to Profile the ex Vivo Hair Growth Inhibition Effect of a Vinca Alkaloid Drug, Colchicine

23 citations , February 2015 in “International Journal of Molecular Sciences”

This study found that colchicine treatment significantly reduced hair fiber elongation in cultured hair follicles and altered protein expression and activity in dermal papilla cells, suggesting a role for the ubiquitin-proteasome system in its effects.

research Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism

52 citations , May 2011 in “APOPTOSIS”

In this study, cisplatin was found to induce cell death in human hair follicle cells through hydroxyl radical generation and Bcl-2 down-regulation, suggesting potential strategies for preventing chemotherapy-induced alopecia.

View more "ubiquitin proteasome pathway" in research →

Community Join

1 / 1000+ results

community GT20029 Will Replace Finasteride For Hair Loss

58 upvotes 4 months ago

GT20029 shows promise as a topical treatment for hair loss, potentially replacing finasteride for some due to its low systemic exposure and ability to degrade androgen receptors. However, skepticism remains about its long-term efficacy and availability, with some users expressing doubt about new treatments consistently failing to reach the market.

View more "ubiquitin proteasome pathway" in community →