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Glossary Protein Degradation

process of breaking down proteins into amino acids

Protein degradation is the process by which cells break down proteins into their constituent amino acids. This is essential for regulating protein levels, removing damaged or misfolded proteins, and recycling amino acids for new protein synthesis. In the context of hair and alopecia, disruptions in protein degradation pathways can affect hair follicle health and contribute to hair loss.

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research Protein degradation: expanding the toolbox to restrain cancer drug resistance

7 citations , January 2023 in “Journal of Hematology & Oncology”

This review discusses how targeting protein degradation processes may help overcome cancer drug resistance, but reports no new clinical results and suggests further research for precise therapeutic strategies.

research Targeted protein degradation of Wnt/β-catenin signaling pathway: an effective strategy for cancer therapy

8 citations , November 2025 in “Journal of Translational Medicine”

This review highlights challenges in developing drugs targeting the Wnt/β-Catenin signaling pathway for cancer due to its complexity and essential roles in normal tissue. It explores targeted protein degradation technology as a promising strategy to overcome these challenges, suggesting potential new avenues for drug development.

research De Novo-Designed Bifunctional Proteins for Targeted Protein Degradation

August 2026 in “Journal of the American Chemical Society”

This study designed a new bifunctional protein that successfully degrades the cancer target BCL-xL in cells, inducing apoptosis with high binding success rates.

research De novo designed bifunctional proteins for targeted protein degradation

February 2026

This study demonstrated that de novo designed bifunctional proteins can target and degrade BCL-xL, leading to cell apoptosis, suggesting a new approach to targeted protein degradation therapy.

research Proteolysis‐targeting chimeras in cancer therapy: Targeted protein degradation for next‐generation treatment

3 citations , October 2025 in “Cancer”

This review highlights the potential of PROTACs to transform cancer treatment by selectively degrading oncogenic proteins, overcoming drug resistance, and reducing toxicity; it also discusses challenges in optimizing these therapies for personalized applications.

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community Sometimes the hair loss was in our control the whole time

833 upvotes 1 year ago

The conversation discusses hair loss and the potential impact of diet and lifestyle changes, particularly increased protein intake, on hair health. The original poster shared their experience of improved hair appearance after weight loss and dietary changes, despite skepticism from others about lighting differences in photos and the effectiveness of diet alone without finasteride or minoxidil.

community AH-001 another topical AR degrader beside GT20029, completed Phase I

8 upvotes 10 months ago

AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.

community Better Than Minoxidil? Topical Sodium Valproate

50 upvotes 1 year ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

14 upvotes 3 years ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Research: Minoxidil grows hair by suppressing androgen activity (DHT) in hair follicles.

43 upvotes 6 years ago

Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hair growth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.

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