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GlossaryProtein Degradation

process of breaking down proteins into amino acids

Protein degradation is the process by which cells break down proteins into their constituent amino acids. This is essential for regulating protein levels, removing damaged or misfolded proteins, and recycling amino acids for new protein synthesis. In the context of hair and alopecia, disruptions in protein degradation pathways can affect hair follicle health and contribute to hair loss.

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community Is GT20029 a cure for further hairloss? Also what do you estimate its price to be?

in Research/Science 9 upvotes 1 year ago

The conversation discusses the potential of GT20029 to stop hair loss and possibly regrow hair, considering the body's regenerative abilities. No specific treatments were mentioned due to the original post being removed.

community Found it. Sulforaphane, a phytochemical in broccoli sprouts, promotes hair growth (60% regeneration in mice) by accelerating the degradation of DHT.

111 upvotes 7 years ago

Sulforaphane, found in broccoli sprouts, promotes hair growth by degrading DHT. Users discuss its potential benefits and joke about unconventional application methods.

community 21M with a nasty case of MPB; Heres what's on my radar for the future.

in Research/Science 14 upvotes 2 years ago

Hopeful treatments for hair loss, including Verteporfin, Androgen Receptor Degradation, and SCUBE3. These treatments offer potential solutions to slow or stop the effects of androgens on the scalp.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

in Research/Science 15 upvotes 1 year ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Kintor has announced the results for their human Phase I trials of GT20029

in Research/Science 253 upvotes 2 years ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 4 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Is GT20029 supposed to regrow hair as well?

in Treatment 10 upvotes 1 year ago

The user is considering switching from finasteride to dutasteride for hair loss. They are unsure if GT20029 can regrow hair, particularly on the temples. Another user mentions that regrowth on finasteride can take up to 2 years.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 122 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 8 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 6 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

in Microneedling 1 upvotes 7 months ago

The conversation discusses microneedling techniques and the use of Minoxidil, copper peptides, EGF, FGF, ceramides, and hydration serums to enhance hair growth. It explores optimizing scalp conditions and the potential benefits of various compounds in conjunction with microneedling.

community I destroyed my scalp so you wouldn't have to: here's what happens when you quit topical minoxidil

in Minoxidil 280 upvotes 1 year ago

Quitting minoxidil can lead to significant hair loss, even in areas that were not thinning before, as hair becomes reliant on the treatment. Some users also report losing hair gains when stopping minoxidil despite taking finasteride.

community Father trying to save his 17 year old son from MPB

in Progress Pictures 160 upvotes 2 years ago

Father assists son with hair loss using Finasteride Propecia. Son's hair improves, considers adding Minoxidil or Dutasteride for better results.

community Vegan Protein Powder Make Loss Worse?

in Female 2 upvotes 4 months ago

A user is experiencing genetic hair loss and is using spironolactone and minoxidil without success. They are considering switching to vegan protein powder due to digestive issues and are concerned if it will worsen hair loss.

community Does whey protein and creatine aggravate hair loss?

in Research/Science 82 upvotes 1 year ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community Can Soy Protein slowing down baldness?

in Research/Science 1 upvotes 1 year ago

Eating soy protein daily might slow down baldness due to its estrogen-stimulating effects. The user cannot use finasteride because it causes insomnia.

community The Korean began to suspect something. But they understood the mechanism to some extent. ( Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor)

in Research 86 upvotes 3 weeks ago

Cold shock therapy may promote hair growth by stimulating follicular muscles and affecting stem cells. The exact mechanisms and full range of elements involved are not yet fully understood.

community Just sharing my holy grails. I have SO many baby hairs. I suffered with telogen effluvium and personally adding in a protein shake a day helped tremendously, I didn’t realize how packed full of vitamins they were. I used TOPICAL minox and had an elevated heart rate

in Treatment 6 upvotes 11 months ago

The user experienced an elevated heart rate from using topical Minoxidil and discontinued its use. They found that adding a daily protein shake helped with telogen effluvium.

community Expectations control for SCUBE3

in Research/Science 21 upvotes 9 months ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

community Twist1 Group Buy: Yes it’s that easy

in Research/Science 39 upvotes 2 years ago

A group buy for testing a compound targeting Twist1 protein as a potential hair loss treatment. Inhibiting Twist1, which keeps hair follicles in growth phase, may prevent hair loss with minimal side effects.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 1 year ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community Supplements for hair growth (Alcoholics, Smokers; and Gym Goers)

in Treatment 6 upvotes 5 months ago

A user shared their experience with hair loss and recommended supplements like magnesium, vitamin D, vitamin C, zinc, iron, and protein, along with using a dermaroller. They noted benefits such as accelerated fat loss, muscle growth, better digestion, increased testosterone, and improved hair and skin quality.

community 3 months’ progress - topical minox - 32F

in Progress Pictures 49 upvotes 6 months ago

A user shared 3 months of hair loss progress using topical minoxidil 5%, biotin, and increased protein. The user noted steady improvement and the benefit of progress pictures.

community I know why people are non responder to hair treatment

in Minoxidil 7 months ago

Improving diet and taking supplements like Biotin, B12, D3, iron, zinc, and protein can enhance the effectiveness of hair treatments. However, responses to treatments like Minoxidil and finasteride vary, and some users report no improvement despite a good diet.

community I know I'm lucky enough to reverse and keep my hair

in Progress Pictures 6 upvotes 8 months ago

The individual reversed their hair loss using oral dutasteride and topical minoxidil, and experienced side effects including low libido, tiredness, and brain fog. They started treatment at age 26 and have a high-protein diet and exercise regularly.

community Nine Month Progress: Bless The Person Who Developed Finasteride And Minoxidil (20M)

in Progress Pictures 592 upvotes 1 year ago

A user shared a nine-month hair regrowth progress using 5mg oral Minoxidil and 1.25mg oral Finasteride daily, with noticeable improvement and no side effects, despite a high-protein diet, occasional smoking, and regular exercise. They also mentioned using keto shampoo and having naturally increased body hair by about 10%.

community My Telogen Effluvium journey after a bad Keratin Treatment

in Female 6 upvotes 1 year ago

A user shared their experience with telogen effluvium triggered by a keratin treatment, leading to significant hair loss. They found improvement using aloe vera with rosemary, a protein and iron-rich diet, and patience.

community When you start Fin for the first time and document progress.

in Satire 409 upvotes 1 year ago

A user's experience with using Fin for hair loss, which includes shedding and regrowth, potential side effects, and the use of supplements, protein, and exercise as additional treatments.

community Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China

in Technology 14 upvotes 3 years ago

The conversation discusses the approval of Kintor Pharmaceutical's AR-PROTAC (GT20029) for clinical trials in China for acne and androgenic alopecia. One user expresses optimism about new treatments being developed and seeks clarification on how the new drug works, specifically if it temporarily degrades the AR protein to reduce DHT sensitivity in hair follicles.