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    Glossary Proteasome Inhibitors

    drugs that block protein-degrading complexes in cells

    Proteasome inhibitors are drugs that block the action of proteasomes, which are protein complexes in cells responsible for degrading unneeded or damaged proteins. By inhibiting proteasomes, these drugs can disrupt the regulated degradation of proteins, leading to the accumulation of defective proteins and potentially inducing cell death. This mechanism is particularly useful in treating certain cancers, as cancer cells are more reliant on proteasomes for their rapid growth and survival.

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    1. Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Chemistry & biology · 2012 · 474 citations
    2. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    3. Nagashima-Type Palmoplantar Keratosis: A Common Asian Type Caused by SERPINB7 Protease Inhibitor Deficiency Journal of Investigative Dermatology · 2014 · 24 citations
    4. Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis Journal of Investigative Dermatology · 1999 · 13 citations
    5. Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403. PubMed · 2001 · 1 citations
    6. Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle Journal of Cell Science · 1995 · 37 citations
    7. Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target Journal of Medicinal Chemistry · 2021 · 3 citations
    8. Virtual Screening of Potential Inhibitors for SARS-CoV-2 Main Protease 2020 · 8 citations
    9. Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin Genetics in medicine · 2018 · 10 citations
    10. 190 Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin 2019
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