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    Glossary Proteasome Inhibitors

    drugs that block protein-degrading complexes in cells

    Proteasome inhibitors are drugs that block the action of proteasomes, which are protein complexes in cells responsible for degrading unneeded or damaged proteins. By inhibiting proteasomes, these drugs can disrupt the regulated degradation of proteins, leading to the accumulation of defective proteins and potentially inducing cell death. This mechanism is particularly useful in treating certain cancers, as cancer cells are more reliant on proteasomes for their rapid growth and survival.

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    1. Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Chemistry & biology · 2012 · 474 citations
    2. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    3. Nagashima-Type Palmoplantar Keratosis: A Common Asian Type Caused by SERPINB7 Protease Inhibitor Deficiency Journal of Investigative Dermatology · 2014 · 24 citations
    4. Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis Journal of Investigative Dermatology · 1999 · 13 citations
    5. Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403. PubMed · 2001 · 1 citations
    6. Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle Journal of Cell Science · 1995 · 37 citations
    7. Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target Journal of Medicinal Chemistry · 2021 · 3 citations
    8. Virtual Screening of Potential Inhibitors for SARS-CoV-2 Main Protease 2020 · 8 citations
    9. Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin Genetics in medicine · 2018 · 10 citations
    10. 190 Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin 2019
    11. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    12. Protease activity, localization and inhibition in the human hair follicle International Journal of Cosmetic Science · 2013 · 11 citations
    13. Message of protease nexin-1 is expressed in human dermal papilla cells and is affected by androgen Journal of dermatological science · 1998
    14. Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis Experimental Dermatology · 2007 · 21 citations
    15. Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs Scientific Reports · 2016 · 34 citations
    16. NF-κB in biology and targeted therapy: new insights and translational implications Signal transduction and targeted therapy · 2024 · 1 citations
    17. 440 Topical application of anti-cancer drug Bortezomib stimulates proliferation of follicular cells and induces expression of hair keratins via GATA-3 transcription factor 2016
    18. Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching (FRAP) Is an Integrated Measure of Receptor Function Molecular Medicine · 2004 · 31 citations
    19. 증례 : 몸통의 다발성 판으로 나타난 Bortezomib에 의한 약물 발진 2예 대한피부과학회지 · 2016
    20. Adverse Drug Reactions in HIV/AIDS Patients on Highly Active Antiretro Viral Therapy: A Review of Prevalence NEWPORT INTERNATIONAL JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES · 2023 · 24 citations
    21. Pegylated-interferon-α<sub>2a</sub>in clinical practice: how to manage patients suffering from side effects Expert Opinion on Drug Safety · 2011 · 17 citations
    22. Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract Pharmacology Research & Perspectives · 2020 · 15 citations
    23. Central centrifugal cicatricial alopecia amalgamated with alopecia areata: immunologic findings Our Dermatology Online · 2014 · 1 citations
    24. Interaction of antiretroviral medications with finasteride Journal of the International AIDS Society · 2012
    25. MOLECULAR AND CELLULAR BASIS OF EXOGEN AND ANAGEN INDUCTION Durham e-Theses (Durham University) · 2007
    26. Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer International Journal of Molecular Medicine · 2011 · 18 citations
    27. 546 Epidermal growth factor receptor as a key regulator of the immune privilege Journal of Investigative Dermatology · 2022
    28. Netherton Syndrome Harper's Textbook of Pediatric Dermatology · 2019
    29. Human epidermal transglutaminase. Preparation and properties. Journal of Biological Chemistry · 1976 · 138 citations
    30. Soymilk reduces hair growth and hair follicle dimensions Experimental dermatology · 2001 · 23 citations