Resveratrol Derivatives: A Patent Review (2009–2012)

    September 2013 in “ Expert Opinion on Therapeutic Patents ”
    John M. Pezzuto, Tamara P. Kondratyuk, Talysa Ogas
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    TLDR New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.
    The document reviews patents on resveratrol derivatives from 2009 to 2012, highlighting their potential in treating various health conditions, including cancer, neurodegenerative diseases, metabolic disorders, and inflammatory skin conditions. It emphasizes the need for more research to understand the structure-activity relationships and improve bioavailability for clinical use. The review notes the promise of pterostilbene in combination therapies, the efficacy of boronic acid chalcone analogs against cancer cell lines, and the potential of resveratrol in treating acne vulgaris and Alzheimer's Disease. It also discusses the role of resveratrol as a caloric restriction mimetic and its activation of SIRT1 and PPARs. Despite the promising nature of these derivatives, none are currently in clinical use, and more investment in research is needed to realize their therapeutic potential. The review concludes that while the potential benefits are significant, further studies are required to determine the efficacy and safety of resveratrol derivatives in long-term clinical trials.
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