NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications
March 2024
in “
Signal transduction and targeted therapy
”
TLDR NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
NF-κB signaling, initially identified for its role in inflammatory responses, has been found to be involved in various signaling mechanisms, biological processes, and human diseases. This review details the composition, activation, and regulation of NF-κB signaling, its interaction with other pathways (e.g., PI3K/AKT, MAPK, JAK-STAT), and its roles in inflammation, immune regulation, and the tumor microenvironment. NF-κB signaling is implicated in numerous diseases, including cancers, autoimmune diseases, cardiovascular and metabolic diseases, neurological disorders, and COVID-19. Therapeutic approaches targeting NF-κB include IKK inhibitors, monoclonal antibodies, proteasome inhibitors, and CAR-T therapy. The review aims to provide a comprehensive understanding of NF-κB signaling to guide future research and clinical applications.
