Theoretical Evaluation of Interaction of Some Dibenzo Derivatives on Both Androgen Receptor and 5-Alpha-Reductase Enzyme

This research evaluated the interaction of 15 Dibenzo derivatives with the androgen receptor and 5α-reductase enzyme, which are involved in prostate cancer. Using a Docking model with flutamide, dutasteride, and finasteride as theoretical tools, the study found that derivatives 9, 11, and 15 could interact with the androgen receptor, while derivatives 2, 5, and 13 may interact with the 5α-reductase enzyme. These findings suggest that certain Dibenzo derivatives could be promising candidates for prostate cancer treatment.