5α-Reduced Glucocorticoids: A Story of Natural Selection

September 2011 in “ Journal of Endocrinology ”

Mark Nixon, Rita Upreti, Ruth Andrew

5α-reduced glucocorticoids 5α-reductase isozymes SRD5A1 SRD5A2 steroid metabolism prostate cancer PCOS glucocorticoids anti-inflammatory properties 5α-reductase inhibitors 5-alpha-reduced glucocorticoids 5-alpha-reductase isozymes polycystic ovary syndrome

Studysummary This study suggests that 5α-reduced glucocorticoids may have anti-inflammatory potential and could serve as biomarkers for liver inflammation in metabolic disease, with implications for drug development.

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Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

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This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.

research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

260 citations , July 2010 in “Cell”

This study identifies mutations in the SRD5A3 gene as a cause of a new type of congenital disorder of glycosylation, impacting mental, ophthalmologic, and cerebellar functions.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations , February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.

research Sexual Dimorphism of Growth Plate Prehypertrophic and Hypertrophic Chondrocytes in Response to Testosterone Requires Metabolism to Dihydrotestosterone by Steroid 5-Alpha Reductase Type 1

27 citations , February 2005 in “Journal of Cellular Biochemistry”

This study found that rat male costochondral chondrocytes, unlike female chondrocytes, respond to testosterone through metabolism to dihydrotestosterone, which shows a maturation-state dependent effect in male growth plate cells.

research Analysis of Genetic Polymorphisms of Steroid 5α-Reductase Type 1 and 2 Genes in Korean Men with Androgenetic Alopecia

15 citations , April 2003 in “Journal of Dermatological Science”

This study found no significant associations between the polymorphisms of SRD5A1 and SRD5A2 genes and androgenetic alopecia, clinical types of baldness, or response to finasteride in Koreans.

research Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1

56 citations , December 2002 in “The Journal of Clinical Endocrinology & Metabolism”

This study suggests that in human osteoblast-like cells, the 5alpha-reductase type 1 isozyme predominantly catalyzes the conversion of testosterone to DHT, which may play a role in bone homeostasis.

research Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin

45 citations , September 2000 in “Archives of dermatology”

This study found that 5alpha-reductase type 1 localizes specifically to sebaceous glands in both normal and acne follicles, suggesting its role in sebum regulation.

research 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla

41 citations , March 1998 in “Archives of Dermatological Research”

This study found that androgen metabolism within hair follicles varies significantly between compartments, with dermal papillae showing high 5α-reductase activity, suggesting a key role in androgen-driven hair growth responses.

Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats

research Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats

26 citations , November 1993 in “Progress in Neuro-psychopharmacology & Biological Psychiatry”

This study reported that prenatal exposure to dihydrotestosterone altered long-term androgen metabolism in juvenile male rats, suggesting different regulatory mechanisms for 5a-reductase in hypothalamic versus pituitary tissues.

research In Vivo Uptake and Metabolism of Testosterone by the Skin and Other Tissues of the Rat

8 citations , May 1982 in “Journal of Endocrinology/Journal of endocrinology”

This study suggests that in rat skin, testosterone itself may play a more significant role in androgen action than 5α-dihydrotestosterone, unlike in the prostate where 5α-DHT is more dominant.