5α-Reduced Glucocorticoids: A Story of Natural Selection

    September 2011 in “ Journal of Endocrinology ”
    Mark Nixon, Rita Upreti, Ruth Andrew
    Studysummary This study suggests that 5α-reduced glucocorticoids may have anti-inflammatory potential and could serve as biomarkers for liver inflammation in metabolic disease, with implications for drug development.
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    Research cited in this study 10

    1. Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride Hormone Molecular Biology and Clinical Investigation · 2010
    2. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010
    3. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    4. Sexual Dimorphism of Growth Plate Prehypertrophic and Hypertrophic Chondrocytes in Response to Testosterone Requires Metabolism to Dihydrotestosterone by Steroid 5-Alpha Reductase Type 1 Journal of Cellular Biochemistry · 2005
    5. Analysis of Genetic Polymorphisms of Steroid 5α-Reductase Type 1 and 2 Genes in Korean Men with Androgenetic Alopecia Journal of Dermatological Science · 2003
    6. Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1 The Journal of Clinical Endocrinology & Metabolism · 2002
    7. Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin Archives of dermatology · 2000
    8. 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla Archives of Dermatological Research · 1998
    9. Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats Progress in Neuro-psychopharmacology & Biological Psychiatry · 1993
    10. In Vivo Uptake and Metabolism of Testosterone by the Skin and Other Tissues of the Rat Journal of Endocrinology/Journal of endocrinology · 1982

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    1. Age-Dependent Regulation by Androgens of Gene Expression in the Anterior Hypothalamus and Stress-Induced Release of Adrenal Hormones in Adolescent and Adult Male Rats Journal of neuroendocrinology · 2019