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    Research 10 of 1000+

    1. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011 · 218 citations
    2. Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2 Archiv Der Pharmazie · 2002 · 8 citations
    3. Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021
    4. Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin Archives of dermatology · 2000 · 45 citations
    5. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    6. Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-Reductase: evidence for mechanism-Based inhibition by finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1998 · 25 citations
    7. 5α‐Reductase Isozymes and Androgen Actions in the Prostate Annals of the New York Academy of Sciences · 2009 · 93 citations
    8. Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005 · 18 citations
    9. The 5α-Recluctase System and Its Inhibitors Dermatology · 1996 · 124 citations
    10. Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase Tetrahedron Letters · 1995 · 20 citations
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    Community 10 of 1000+

    1. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    2. Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis? Reddit · 26 Jun 2020
    3. Does anyone know about the mechanism between creatine and 5-alpha reductase? Reddit · 25 Mar 2019
    4. Does caffeine inhibit 5-α-reductase? Reddit · 27 Dec 2019
    5. 17-alpha-estradiol/Alfatradiol how does it Work for Hair loss? Reddit · 17 Dec 2024
    6. Mechanism of action of alfatradiol (17 alpha estradiol) Reddit · 29 May 2024
    7. Approximation of Scalp DHT Suppression Between 0.05 mg to 2.5 mg Reddit · 28 Jan 2024
    8. fin 0.5 mg everday 6 months update Reddit · 10 Nov 2023
    9. I've been afraid to start Finasteride treatment for 5 years, on it for 2 weeks, regret that hadn't started it earlier and here's my story Reddit · 28 Sept 2021
    10. 4 months on oral dutasteride + one month and 3 weeks on topical minoxidil 5% Reddit · 23 May 2026
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    Learn 6 of 24

    1. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    2. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    3. Saw Palmetto Palm-berry extract taken as a supplement
    4. Azelaic Acid Acid used in acne and rosacea creams
    5. Rosemary Herb whose oil is used in hair care
    6. Neem Oil Oil from the neem tree, used in traditional remedies
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