TLDR Some cannabinoid derivatives may be more effective than current drugs at targeting proteins relevant to prostate cancer treatment.
The theoretical research evaluated the interaction of twenty cannabinoid derivatives with either androgen receptor or 5a-reductase enzyme. The results showed that cannabinoid derivatives 6, 13, 16, and 20 had higher affinity for the androgen receptor surface compared to testosterone, dihydrotestosterone, and flutamide. Additionally, cannabinoid derivatives 1, 3, 14, and 18 showed higher affinity for the 5a-reductase enzyme compared to dutasteride and finasteride. This suggests that these cannabinoid derivatives could act as androgen receptor inhibitors and 5a-reductase enzyme inhibitors, making them potential candidates for the treatment of prostate cancer.
5 citations
,
January 2022 in “Clinical cancer investigation journal” Certain Dibenzo derivatives may help treat prostate cancer.
30 citations
,
October 2020 in “Nature Communications” Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.
18 citations
,
December 2005 in “Journal of Medicinal Chemistry” A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.
97 citations
,
March 2009 in “Dermato-endocrinology” Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.
59 citations
,
November 2018 in “Psychoneuroendocrinology” Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.
22 citations
,
November 2011 in “Journal of Analytical Toxicology” Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.
3 citations
,
December 2022 in “Cells” Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.
New treatments for hair loss should target eight main causes and use specific plant compounds and peptides for better results.
