TLDR Acne is caused by multiple factors including oil production, bacteria, inflammation, and possibly diet and environment.
The 2014 review article examines the complex causes of acne vulgaris, a condition affecting a majority of young people. It emphasizes the multifactorial nature of acne, involving sebum production, follicular keratinization, bacterial colonization, particularly by P. acnes, and inflammatory responses. The article notes that while sebum production is linked to acne, it is not the sole cause, as other conditions with high sebum do not result in acne. Advances in understanding the role of P. acnes at the strain level and its virulent properties could lead to targeted acne treatments. The review also discusses the immune response to P. acnes, the role of TLR2, oxidative stress, hormonal influences, and genetic factors in acne development. A study involving 32 acne patients and 34 controls indicated higher oxidative stress in those with acne. The document suggests environmental factors, diet, and smoking also contribute to acne, and highlights the importance of inflammatory processes, suggesting acne be considered a chronic inflammatory dermatosis.
9 citations,
November 2013 in “Presse Medicale” The document concludes that managing female hyperandrogenism requires a combination of identifying the cause, lifestyle changes, medication, and cosmetic treatments.
9 citations,
January 2013 in “BioMed research international” The conclusion suggests a new acne treatment that controls bacteria by reducing water in the skin's pores using sugar-like substances.
466 citations,
June 2009 in “Experimental dermatology” We now understand more about what causes acne and this could lead to better, more personalized treatments.
63 citations,
May 2009 in “Dermato-endocrinology” Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.
216 citations,
May 2003 in “Journal of Investigative Dermatology” Glycerol is essential for skin hydration in mice without sebaceous glands.
January 2019 in “ARC journal of pharmaceutical sciences” Acne can be managed with various treatments and requires psychological support due to its emotional impact.
18 citations,
June 2019 in “Clinical research in dermatology” Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.
research Acne
58 citations,
January 1997 in “Dermatologic Clinics” Acne significantly affects mental health and quality of life, with research suggesting hormonal and genetic factors in its development and emphasizing early treatment to prevent scarring.
4 citations,
December 2021 in “Experimental and Therapeutic Medicine” Adult female acne is complex and requires a combination of treatments for effective management.
1 citations,
January 2010 in “Serbian Journal of Dermatology and Venereology” The document concludes that effective acne treatment requires a personalized combination of therapies and long-term commitment, with retinoids being important for maintenance.
