Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice

May 2003 in “ Journal of Investigative Dermatology ”

Joachim W. Fluhr, Kenneth R. Feingold, Barbara E. Brown, Philip W. Wertz, Debra Crumrine, John P. Sundberg, Kenneth R. Feingold, Peter M. Elias

glycerol stratum corneum sebaceous gland asebia mice topical application sebum-like lipids hydration sebaceous gland lipids skin hydration skin barrier skin lipids

TLDR Glycerol is essential for skin hydration in mice without sebaceous glands.

The study found that sebaceous gland-deficient (asebia) mice had significantly reduced stratum corneum (SC) hydration, despite normal barrier function, due to decreased sebaceous gland lipids. Topical glycerol application, but not synthetic sebum-like lipids, normalized SC hydration, indicating glycerol's critical role. Glycerol content in asebia mice was 85% lower than in normal mice, underscoring the importance of sebaceous-gland-derived glycerol in maintaining SC hydration.

View this study on jidonline.org →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

179 citations, June 2000 in “The American journal of pathology”

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

research Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias

57 citations, August 1999 in “Archives of dermatology”

Hair follicles grow hair and release it through the skin.

research Mouse Models for the Study of Human Hair Loss

36 citations, October 1996 in “Dermatologic Clinics”

Mice are useful for researching human hair loss and testing treatments, despite some differences between species.

Similar Research

5 / 865 results

research Acne Vulgaris

March 2017 in “InTech eBooks”

Acne vulgaris is a common skin condition that can cause low self-esteem and depression, and early treatment is important to prevent scarring.

research The Aetiopathogenesis of Acne Vulgaris: What's New?

14 citations, April 2014 in “International Journal of Cosmetic Science”

Acne is caused by multiple factors including oil production, bacteria, inflammation, and possibly diet and environment.

research A Honey Trap for the Treatment of Acne: Manipulating the Follicular Microenvironment to Control Propionibacterium Acnes

9 citations, January 2013 in “BioMed research international”

The conclusion suggests a new acne treatment that controls bacteria by reducing water in the skin's pores using sugar-like substances.

research Clinical Snippets: Dermatological Findings and Insights

1 citations, May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

A hormone affects hair growth, certain molecules may prevent skin damage, a skin disease is linked to immune cells, glycerol helps skin hydration, and psoriasis treatment trials need improvement.

research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

3 citations, December 2022 in “Cells”

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.

Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice

Research cited in this study

research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

research Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias

research Mouse Models for the Study of Human Hair Loss

Related Community Posts Join

community Lavdik Hair Growth Serum?

community Carrier for homemade topical Finasteride

community Stemoxydine carrier for finasteride

community Topical finasteride dosage in grams

community Alfatradiol as a base for Topical Finasteride