Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice

May 2003 in “ Journal of Investigative Dermatology ”

Joachim W. Fluhr, Kenneth R. Feingold, Barbara E. Brown, Philip W. Wertz, Debra Crumrine, John P. Sundberg, Kenneth R. Feingold, Peter M. Elias

glycerol stratum corneum sebaceous gland asebia mice topical application sebum-like lipids hydration sebaceous gland lipids skin hydration skin barrier skin lipids

TLDR Glycerol is essential for skin hydration in mice without sebaceous glands.

The study investigated the role of glycerol in maintaining stratum corneum (SC) hydration in sebaceous gland-deficient (asebia) mice. It found that glycerol, derived from the hydrolysis of triglycerides in sebaceous glands, was crucial for normal SC hydration. Asebia mice exhibited significantly reduced SC hydration due to decreased glycerol levels, despite having a normal permeability barrier function. Topical application of glycerol effectively restored hydration, whereas other humectants like urea did not. The research highlighted the importance of sebaceous-gland-derived glycerol in skin moisture and suggested potential clinical implications for conditions with absent or reduced sebaceous gland activity.

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Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice

Research cited in this study

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research Mouse Models for the Study of Human Hair Loss

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