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Glossary Skin Lipids

natural fats in the skin's outermost layer

Skin lipids are natural fats found in the outermost layer of the skin, known as the stratum corneum. They play a crucial role in maintaining the skin's barrier function, keeping it hydrated, and protecting it from environmental damage. These lipids include ceramides, cholesterol, and fatty acids, which work together to prevent water loss and shield the skin from harmful substances.

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Research

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research Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli

105 citations , January 2010 in “Mediators of Inflammation”

This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.

research Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

5 citations , February 2025 in “Cell Reports”

In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.

research Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

2 citations , April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that skin surface lipids contain measurable mRNAs, providing a non-invasive way to study skin diseases, with specific gene expression changes observed in atopic dermatitis patients.

research Lipid nanocosmeceuticals: a novel approach to skin therapy for anti-aging and skin disorders

1 citations , October 2025 in “Beni-Suef University Journal of Basic and Applied Sciences”

This study reviews lipid-based nanocosmeceuticals and reports that they enhance therapeutic effectiveness in dermatological applications by improving skin hydration, reducing wrinkles, and effectively managing conditions like psoriasis and eczema, though further large-scale trials and regulatory alignment are needed for clinical use.

research The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

128 citations , March 2016 in “Advanced Pharmaceutical Bulletin”

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.

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Community Join

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community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

131 upvotes 1 year ago

Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

community Lipisomal Solution (Dutasteride / Tretinoin & Minoxidil & Tretinoin) Horror Story Warning

in Update 12 upvotes 1 year ago

Using liposomal solutions with dutasteride, minoxidil, and tretinoin worsened hair loss due to buildup and scalp issues. Consulting a professional and returning to simpler treatments like finasteride and minoxidil improved the situation.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community So does oral minoxidil age your skin or not

43 upvotes 2 years ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Topical Finasteride that doesn’t go systematic is the cure

3 upvotes 1 year ago

Topical finasteride that doesn't penetrate the skin could potentially treat hair loss without side effects. Current challenges include finding a formulation that remains on the scalp without increasing blood levels.

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Learn

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learn Ketoconazole

antifungal with some anti-androgenic benefits, often used as a shampoo

learn sh-Polypeptide-7

learn Overview

learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn retinol

How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.

learn Hyaluronic Acid

Does hyaluronic acid really hydrate the scalp, or is it mainly for skin care? Hyaluronic acid can hydrate the scalp, but its effectiveness may vary.

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Clinics

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Experts

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36
SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin