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Glossary Skin Surface Lipids

mixture of oils and fats secreted onto skin's surface

Skin Surface Lipids (SSL) are a mixture of oils and fats produced by the sebaceous glands and secreted onto the skin's surface. They play a crucial role in maintaining the skin's barrier function, hydration, and protection against microbial invasion.

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Research

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research Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli

105 citations , January 2010 in “Mediators of Inflammation”

This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.

research Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

10 citations , March 2022 in “Communications biology”

In this study, researchers found that non-invasive analysis of skin surface lipid RNAs revealed alterations in gene expression patterns associated with atopic dermatitis, suggesting its potential for understanding skin disease pathophysiology.

research Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

2 citations , April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that skin surface lipids contain measurable mRNAs, providing a non-invasive way to study skin diseases, with specific gene expression changes observed in atopic dermatitis patients.

research Optimization of menthol-loaded nanocapsules for skin application using the response surface methodology

25 citations , July 2019 in “Journal of drug delivery science and technology”

This study developed lipid-core nanocapsules for encapsulating menthol, improving its solubility and thermal stability, and demonstrated their safety and rapid skin absorption in ex vivo tests, highlighting potential applications for cosmeceuticals.

research Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenetic alopecia

52 citations , December 2000 in “Archives of Dermatological Research”

This study found that the stratum corneum of scalp skin in humans has distinct functional characteristics compared to the facial skin and volar forearm, including higher hydration levels and intermediate epidermal turnover rates.

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community So does oral minoxidil age your skin or not

43 upvotes 2 years ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Topical Finasteride that doesn’t go systematic is the cure

3 upvotes 1 year ago

Topical finasteride that doesn't penetrate the skin could potentially treat hair loss without side effects. Current challenges include finding a formulation that remains on the scalp without increasing blood levels.

community PP405 is NOT gray market jxl069

in Technology 26 upvotes 8 months ago

PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

community The Worst Hair Loss Condition You (MAY) have: LPP

48 upvotes 2 years ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Why everyone should be using topical Dutasteride

45 upvotes 3 months ago

Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

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Clinics

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Hair Loss Treatments
Surface ClinicShipley, England · GB

Experts

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SMP Specialist
Noelle Skin
Nice, France

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