TLDR A new non-invasive method can analyze skin mRNA to understand skin diseases better.
This study developed a non-invasive method to analyze human mRNA from skin surface lipids (SSLs), protected from degradation by sebum. The method, validated with samples from 29 healthy subjects and 30 patients with atopic dermatitis (AD), revealed significant differences in gene expression between the groups. AD patients showed increased expression of inflammation-related genes and decreased expression of skin barrier and lipid synthesis-related genes. This approach offers a promising tool for understanding skin diseases and potential biomarkers, providing a comprehensive and non-invasive way to profile skin mRNAs.
Cited in this study
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60 citations
,
February 2013 in “Cell reports” The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.
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,
January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.
138 citations
,
June 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
179 citations
,
June 2000 in “The American journal of pathology” The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.
October 2018 in “Springer eBooks” The document concludes that various hair disorders have different treatments, including medication, surgery, and addressing underlying causes.
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,
May 2018 in “Experimental Dermatology” The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.
May 2017 in “Journal of Dermatological Science” Certain flavonoids can improve the growth of pigmented hair in mice.