Non-Invasive Human Skin Transcriptome Analysis Using mRNA in Skin Surface Lipids

March 2022 in “ Communications biology ”

Tsukasa Inoue, Tetsuya Kuwano, Yuya Uehara, Masayuki Yano, Naoki Oya, Naoto Takada, So Tanaka, Yui Ueda, Akira Hachiya, Yūzō Takahashi, Noriyasu Ota, Takatoshi Murase

mRNA skin surface lipids sebum atopic dermatitis gene expression inflammation-related genes skin barrier lipid synthesis biomarkers SSLs AD

Studysummary In this study, researchers found that non-invasive analysis of skin surface lipid RNAs revealed alterations in gene expression patterns associated with atopic dermatitis, suggesting its potential for understanding skin disease pathophysiology.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on nature.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations , February 2013 in “Cell reports”

This study demonstrates that c-MYC overexpression in sebaceous glands affects differentiation via a regulatory axis involving the androgen receptor and p53, influencing carcinoma formation outcomes.

research TGFβ Signaling Regulates Lipogenesis in Human Sebaceous Gland Cells

44 citations , January 2013 in “BMC Dermatology”

This study found that TGFβ signaling is essential for keeping sebocytes undifferentiated by reducing lipid-related gene expression, using a novel human sebocyte culture model.

research The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle

87 citations , July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that beard hair medulla cells express an unexpected range of keratins, showing variability and promiscuous behavior in keratin interactions distinct from other hair follicle cells.

research Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate

193 citations , May 2008 in “Development”

This study found that activating β-catenin signaling in embryonic epidermis promoted hair follicle characteristics at the expense of normal epidermal differentiation, leading to early pigmentation and innervation.

research Hair Follicle-Specific Keratins And Their Diseases

138 citations , March 2007 in “Experimental cell research”

This review discusses hair keratins and hair follicle-specific epithelial keratins and their association with inherited hair disorders, reporting no new clinical results.

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle

93 citations , July 2006 in “Journal of Investigative Dermatology”

This study describes the expression patterns of type I inner root sheath keratin proteins K25–K28 in human hair follicles, highlighting their distinct distribution within different layers.

research The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff

241 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the roles of sebaceous gland activity, Malassezia yeast, and individual susceptibility in scalp flaking disorders, including dandruff and seborrheic dermatitis, but reports no new experiment results.

research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

179 citations , June 2000 in “The American journal of pathology”

This study reports that the asebia-2J mutation in mice affects sebaceous gland function and leads to hair follicle destruction, offering a model for human scarring alopecias.