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    Glossary Skin Lipids

    natural fats in the skin's outermost layer

    Skin lipids are natural fats found in the outermost layer of the skin, known as the stratum corneum. They play a crucial role in maintaining the skin's barrier function, keeping it hydrated, and protecting it from environmental damage. These lipids include ceramides, cholesterol, and fatty acids, which work together to prevent water loss and shield the skin from harmful substances.

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    1. Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli Mediators of Inflammation · 2010 · 105 citations
    2. Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis Cell Reports · 2025 · 5 citations
    3. Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 2 citations
    4. Lipid nanocosmeceuticals: a novel approach to skin therapy for anti-aging and skin disorders Beni-Suef University Journal of Basic and Applied Sciences · 2025 · 1 citations
    5. The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study Advanced Pharmaceutical Bulletin · 2016 · 128 citations
    6. The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study. PubMed · 2016 · 71 citations
    7. Cyproterone acetate-loaded nanostructured lipid carriers: effect of particle size on skin penetration and follicular targeting Pharmaceutical development and technology · 2019 · 40 citations
    8. Enhanced skin penetration of lidocaine through encapsulation into nanoethosomes and nanostructured lipid carriers: a comparative study ˜Die œPharmazie · 2016 · 15 citations
    9. Poloxam Thermosensitive Hydrogels Loaded with hFGF2-Linked Camelina Lipid Droplets Accelerate Skin Regeneration in Deep Second-Degree Burns International Journal of Molecular Sciences · 2022 · 8 citations
    10. Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-loaded Nano Lipidic Carriers-infused Topical Gel - In vitro and In vivo Skin Permeation Studies 2023
    11. SKIN TARGETING OF AN OPTIMIZED CAFFEINE NANOSTRUCTURED LIPID CARRIER WITH IMPROVED EFFICIENCY AGAINST CHEMOTHERAPY INDUCED ALOPECIA International Journal of Applied Pharmaceutics · 2022
    12. Skin Targeting of An Optimized Caffeine Nanostructured Lipid Carrier With Improved Efficiency Against Chemotherapy Induced Alopecia Research Square (Research Square) · 2021
    13. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5 Proceedings of the National Academy of Sciences of the United States of America · 2017 · 18 citations
    14. TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function Journal of Investigative Dermatology · 2011 · 22 citations
    15. Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids Communications biology · 2022 · 10 citations
    16. Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics Inflammation and Regeneration · 2018 · 24 citations
    17. Characteristics of Malassezia furfur at various pH and effects of Malassezia lipids on skin cells Applied Microbiology and Biotechnology · 2024 · 7 citations
    18. Transcriptome Analysis Reveals Skin Lipid Metabolism Related to Wool Diameter in Sheep bioRxiv (Cold Spring Harbor Laboratory) · 2016 · 10 citations
    19. A Nutritional Supplement Formulated with Peptides, Lipids, Collagen and Hyaluronic Acid Optimizes Key Aspects of Physical Appearance in Nails, Hair and Skin Journal of nutrition & food sciences · 2012 · 5 citations
    20. Skin-Associated Cartilage Is a Distinct Type of Lipid-Filled Tissue Journal of Investigative Dermatology · 2025 · 3 citations
    21. Effect of an oral probiotic formula on scalp and facial skin condition, glucose, and lipid metabolism 2022 · 1 citations
    22. 1619 Spatial transcriptomic analysis of imiquimod-treated mouse skin reveals deregulation of lipid raft-associated markers which could be reversed by re-introduction of caveolin scaffolding domain peptide Journal of Investigative Dermatology · 2023
    23. Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes Biomolecules & Therapeutics · 2011 · 11 citations
    24. INTRODUCING ELECTROMAGNETIC ENERGY FROM HYDROCOLLOID WOUND DRESSING PASTE PENETRATING A GLASS BARRIER DISRUPTING HUMAN SKIN LIPID DROPLETS SIZE AND MEMBRANES: POSSIBLE IMPLICATIONS IN CANCER CELLS GENESIS AND/OR CURE International journal of research - granthaalayah · 2023 · 1 citations
    25. Dietary lipids are largely deposited in skin and rapidly affect insulating properties Nature Communications · 2025 · 5 citations
    26. Enhanced ex vivo skin retention of bicalutamide using a nano-in-micro composite: Drug-loaded lipid vesicles in a dissolving microarray patch European Journal of Pharmaceutics and Biopharmaceutics · 2025
    27. Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation Antioxidants · 2025 · 36 citations
    28. 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling Journal of Investigative Dermatology · 2025
    29. Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery Advanced NanoBiomed Research · 2024 · 8 citations
    30. Lipid Nanoparticles Based Cosmetics with Potential Application in Alleviating Skin Disorders Cosmetics · 2021 · 59 citations