Pilosebaceous Follicles: Structure, Biochemistry, and Function

January 2019 in “ Springer eBooks ”

Gerd Plewig, Bodo C. Melnik, WenChieh Chen

pilosebaceous follicles sebaceous glands lipid production mTORC1 SREBP-1 PPARγ hormones diet sebum excretion holocrine secretion acne vulgaris immunobiological roles skin glands lipid regulation hormonal impact dietary impact sebum release acne immune roles

TLDR Sebaceous glands play a key role in skin health and conditions like acne.

The document "Pilosebaceous Follicles: Structure, Biochemistry, and Function" provided a comprehensive review of the anatomy, physiology, and biochemical processes of pilosebaceous follicles, with a focus on sebaceous glands. It covered various aspects such as the regulation of lipid production, the role of different signaling pathways (e.g., mTORC1, SREBP-1, PPARγ), and the impact of hormones and diet on sebaceous gland function. The document also discussed the unique features of human sebaceous glands compared to other primates, the involvement of sebaceous lipids in skin health and disease, and the mechanisms of sebum excretion and holocrine secretion. Additionally, it highlighted the importance of sebaceous glands in conditions like acne vulgaris and their broader immunobiological roles.

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research Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ

76 citations , March 2017 in “Clinics in dermatology”

Sex hormones, especially androgens, play a key role in causing acne.

research Beyond Acne: Current Aspects of Sebaceous Gland Biology and Function

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The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

research Linking Diet to Acne Metabolomics, Inflammation, and Comedogenesis: An Update

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Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

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25 citations , June 2014 in “Journal of Endocrinology/Journal of endocrinology”

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

research The Human Hair: From Anatomy to Physiology

107 citations , December 2013 in “International Journal of Dermatology”

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

research A Practical Guide for the Study of Human and Murine Sebaceous Glands In Situ

56 citations , September 2013 in “Experimental Dermatology”

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

research Development and Homeostasis of the Sebaceous Gland

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The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.