Analysis of Histology and Long Noncoding RNAs Involved in the Rabbit Hair Follicle Density Using RNA Sequencing

    January 2021 in “ Research Square (Research Square) ”
    Haisheng Ding, Huiling Zhao, Xiaowei Zhao, Yunxia Qi, Xiaofei Wang, Dongwei Huang
    TLDR Rabbits with high wool production have more hair follicles, influenced by specific long noncoding RNAs.
    This study investigated hair follicle density in Wan strain Angora rabbits with varying wool production levels through histological analysis and RNA sequencing. It found that rabbits with high wool production (HWP) had higher hair follicle density. The study identified 50 differentially expressed long noncoding RNAs (lncRNAs) and 38 genes between high and low wool production groups. Gene ontology analysis highlighted significant enrichment in lipid metabolism and transport processes. Five lncRNAs were identified as potential regulators of hair follicle density and development, with three being validated by q-PCR. The findings provided insights into the molecular mechanisms regulating hair follicle density, particularly the role of lncRNAs.
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