Analyses of Histological and Transcriptome Differences in the Skin of Short-Hair and Long-Hair Rabbits

February 2019 in “ BMC Genomics ”

Haisheng Ding, Huiling Zhao, Guanglong Cheng, Yongxin Yang, Xiaofei Wang, Xiaowei Zhao, Yunxia Qi, Dongwei Huang

histological differences transcriptome differences lipid metabolism apoptosis hair growth

TLDR Hair length in rabbits is linked to differences in lipid metabolism and cell death.

The study analyzed the skin traits and gene expression profiles of short-hair and long-hair rabbits to understand the molecular mechanisms regulating hair growth. It found that long-hair rabbits had a longer anagen phase, promoting continuous hair growth, while short-hair rabbits entered the telogen phase earlier. Transcriptome analysis identified 951 differentially expressed genes, with significant differences in hair follicle development, lipid metabolism, and apoptosis. Keratin genes were up-regulated in long-hair rabbits, and the role of FGF5 and its variants in hair growth regulation was highlighted. These findings suggested potential applications in rabbit breeding and textile industries, with further research recommended to explore candidate genes' roles in hair length regulation.

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