Analyses of Histological and Transcriptome Differences in the Skin of Short-Hair and Long-Hair Rabbits

February 2019 in “ BMC Genomics ”

Haisheng Ding, Huiling Zhao, Guanglong Cheng, Yongxin Yang, Xiaofei Wang, Xiaowei Zhao, Yunxia Qi, Dongwei Huang

histological differences transcriptome differences lipid metabolism apoptosis hair growth

Studysummary In this study, transcriptome analysis suggested that lipid metabolism and apoptosis may be key factors influencing hair length differences between short-hair and long-hair rabbits.

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research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

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research Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

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research The Effects of Melatonin Treatment on Wool Production and Hair Follicle Cycle in Angora Rabbits

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research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

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