Dynamic Wnt5a Expression in Murine Hair Follicle Cycle and Its Inhibitory Effects on Follicular Growth

February 2014 in “ Asian Pacific journal of tropical medicine ”

De-ren Fang, Zhongfa Lv, Gang Qiao

Wnt5a hair follicle cycle in situ hybridization Rhoa β-catenin Rac2 Wnt pathway

Studysummary This study observed that Wnt5a mRNA expression in mice correlates with the hair cycle and inhibits hair follicle growth by antagonizing the Wnts pathway. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the expression of Wnt5a, a member of the Wnt family, during the hair follicle cycle in mice and its potential inhibitory effects on hair follicle growth. Using in situ hybridization, the researchers found that Wnt5a mRNA was expressed from birth and varied throughout the hair cycle, peaking during the advanced growth stage. The study also involved injecting Ad-Wnt5a into mice after hair removal to observe its effects on hair follicle growth. Results showed that Wnt5a expression was associated with decreased levels of Rhoa and β-catenin, and increased Rac2 expression, suggesting an inhibitory effect on hair follicle growth. The findings indicate that Wnt5a acts antagonistically to the Wnt pathway and interferes with hair follicle growth in vivo.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

research The Incidental Pore: CaV1.2 and Stem Cell Activation in Quiescent Hair Follicles

3 citations , June 2013 in “Genes & development”

In their research, Yucel and colleagues found that CaV1.2 is expressed in hair follicle stem cells, facilitating anagen re-entry in a way not dependent on calcium flux.

research State-Dependent Signaling by Cav1.2 Regulates Hair Follicle Stem Cell Function

27 citations , June 2013 in “Genes & development”

This study found that L-type channel blockers can induce hair growth in Timothy syndrome by overcoming delays in anagen phase, suggesting a potential therapeutic role for tissue regeneration.

research Hopx Expression Defines a Subset of Multipotent Hair Follicle Stem Cells and a Progenitor Population Primed to Give Rise to K6+ Niche Cells

74 citations , March 2013 in “Development”

This study found that Hopx labels a long-lived progenitor population in hair follicles, which contributes to hair follicle stem cell homeostasis and has an alternative origin from previously thought progenitors.

Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

74 citations , January 2013 in “Expert Opinion on Biological Therapy”

This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.

research Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling

158 citations , February 2012 in “Journal of Investigative Dermatology”

FGF18 helps keep hair in its resting phase, affecting hair growth cycles.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

This study identified TGF-β2 as a crucial signal in hair follicle stem cell regeneration, highlighting its role in counteracting BMP signaling to promote tissue regeneration.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

This study found that in a population of hair follicles, regenerative cycling stages are regulated by both intrinsic and extrinsic signals, with WNT/BMP signaling mediating interactions among follicles for adaptability.

research EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair

354 citations , February 2011 in “Genes & Development”

This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.

research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

283 citations , February 2011 in “Cell stem cell”

COL17A1 is crucial for preventing hair graying and loss by supporting hair and pigment stem cells.

research Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle

149 citations , June 2010 in “The FASEB journal”

In this study, miR-31 was found to play a significant role in hair cycle regulation in mice by controlling key gene expressions involved in hair growth and differentiation.

research Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle

39 citations , May 2010 in “Stem Cells”

This study reported that disrupting ephrin-Eph interactions in adult mouse skin doubled cell proliferation in the hair follicle and epidermis, suggesting ephrins as negative regulators of proliferation.

research Coexistence of Quiescent and Active Adult Stem Cells in Mammals

1201 citations , January 2010 in “Science”

This review discusses stem cells in the hair follicle, bone marrow, and intestinal epithelium and introduces a model where quiescent and cycling stem cells may coexists in "zoned" configurations.

research Neural Wiskott-Aldrich Syndrome Protein Modulates Wnt Signaling and Is Required for Hair Follicle Cycling in Mice

37 citations , January 2010 in “Journal of Clinical Investigation”

In this study, N-WASP deficiency in mouse skin was found to cause severe alopecia and disrupt hair follicle cycling by 5 months, highlighting its critical role in skin function and Wnt signaling.

research Cutaneous Consequences of Inhibiting EGF Receptor Signaling In Vivo: Normal Hair Follicle Development, But Retarded Hair Cycle Induction and Inhibition of Adipocyte Growth in EgfrWa5 Mice

32 citations , January 2010 in “Journal of Dermatological Science”

In this study, Waved-5 mice with reduced EGFR signaling showed nearly normal skin and hair follicle function but experienced a transient reduction in subcutaneous fat.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.

research Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture

132 citations , September 2009 in “Experimental Dermatology”

This study introduced a new classification system for distinguishing between anagen VI and early catagen stages in human hair follicle organ culture, using it to confirm eflornithine's ability to induce premature catagen.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.