TLDR CaV1.2 helps activate hair follicle stem cells without calcium flux.
Yucel and colleagues discovered that CaV1.2, a subunit of a voltage-gated L-type calcium channel, was expressed in hair follicle stem cells and played a role in the transition of quiescent telogen hair follicles to the active anagen stage. This process was found to be independent of calcium flux, suggesting a novel mechanism for stem cell activation in hair follicles. This finding provided new insights into the regulation of hair follicle cycles and the role of calcium channels in stem cell biology.
Cited in this study
6 / 6 results
27 citations
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June 2013 in “Genes & development” Cav1.2 affects hair growth and could be a target for hair loss treatments.
170 citations
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January 2013 in “Journal of Investigative Dermatology” Wnt ligands are crucial for hair growth and repair.
150 citations
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321 citations
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550 citations
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745 citations
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21 citations
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May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
May 2016 in “Journal of Investigative Dermatology” Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.
