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    Novel Insights Into the Pathways Regulating the Canine Hair Cycle and Their Deregulation in Alopecia X

    October 2017 in “ PLOS ONE ”
    Magdalena A. T. Brunner, Vidhya Jagannathan, Dominik P. Waluk … Monika Maria Welle
    Studysummary This study found that in Pomeranians with Alopecia X, key genes in the Wnt and Shh signaling pathways and stem cell markers are downregulated, which may explain the absence of anagen hair follicles.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 34

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    2. The Modulatable Stem Cell Niche: Tissue Interactions During Hair and Feather Follicle Regeneration Journal of Molecular Biology · 2015
    3. Mapping the Expression of Epithelial Hair Follicle Stem Cell-Related Transcription Factors LHX2 and SOX9 in the Human Hair Follicle Experimental Dermatology · 2015
    4. Deslorelin for the Treatment of Hair Cycle Arrest in Intact Male Dogs Veterinary dermatology · 2014
    5. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    6. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    7. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014
    8. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    9. Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche Nature Reviews Molecular Cell Biology · 2013
    10. Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles Journal of dermatological science · 2013
    11. Tuning Wnt Signals for More or Fewer Hairs Journal of Investigative Dermatology · 2013
    12. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    13. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    14. Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen PLOS ONE · 2012
    15. Canine Noninflammatory Alopecia: A Comprehensive Evaluation of Common and Distinguishing Histological Characteristics Veterinary Dermatology · 2012
    16. Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia Journal of Dermatological Science · 2012
    17. Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions Molecular and Cellular Endocrinology · 2012
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    19. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
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    21. From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber Journal of Investigative Dermatology · 2009
    22. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
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    24. Melatonin and the Hair Follicle Journal of pineal research · 2007
    25. Estrogen Receptor Antagonist and Hair Regrowth in Dogs with Hair Cycle Arrest (Alopecia X) Veterinary dermatology · 2007
    26. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006
    27. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    28. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    29. Estrogen Receptor Evaluation in Pomeranian Dogs with Hair Cycle Arrest (Alopecia X) on Melatonin Supplementation Veterinary dermatology · 2006
    30. Growth Hormone-Responsive Alopecia in Dogs Journal of the American Veterinary Medical Association · 2005
    31. Adrenal Steroid Hormone Concentrations in Dogs with Hair Cycle Arrest (Alopecia X) Before and During Treatment with Melatonin and Mitotane Veterinary dermatology · 2004
    32. Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model Journal of Investigative Dermatology · 2002
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    34. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999

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    1. Novel Insights Into the Pathways Regulating the Canine Hair Cycle and Their Deregulation in Alopecia X PLOS ONE · 2017
    2. Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways InTech eBooks · 2017
    3. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    4. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008