TLDR Deslorelin may help intact male dogs regrow hair from alopecia X, with a 75% success rate and no side effects.
In a study evaluating the efficacy of a 4.7 mg deslorelin implant for treating hair cycle arrest (alopecia X) in dogs, 20 dogs with confirmed alopecia X were treated, including 16 intact males and 4 neutered females from various breeds. The results showed that 12 of the 16 intact male dogs (75%) experienced hair regrowth within 3 months, while no hair regrowth was observed in the neutered female dogs. The overall response rate to the treatment was 60%, with no adverse effects reported. The study concluded that deslorelin may be a viable treatment option for intact male dogs suffering from idiopathic hair cycle arrest and presents an alternative to current therapies and castration.
Cited in this study
6 / 6 results
10 citations
,
September 2013 in “Veterinary dermatology” Medroxyprogesterone injections caused hair regrowth in some dogs with alopecia X.
11 citations
,
January 2007 in “Veterinary dermatology” Fulvestrant at 10 mg/kg does not promote hair regrowth in dogs with alopecia X.
159 citations
,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
15 citations
,
September 2005 in “The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association” Trilostane effectively treated hair loss in Alaskan Malamutes with no adverse effects.
52 citations
,
October 2004 in “Veterinary dermatology” Melatonin and mitotane treatment led to hair re-growth in 62% of dogs with Alopecia X, but this was not always linked to normal hormone levels.
149 citations
,
June 2002 in “Veterinary record/The veterinary record” Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.
1 citations
,
January 2015 in “Genetics and Molecular Research” Stopping S100A3 activity slows down hair growth in mice.
2 citations
,
October 2010 in “Journal of dermatological treatment” External treatments can change hair growth patterns in nude mice.
370 citations
,
September 1999 in “The New England Journal of Medicine” Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.