Deslorelin for the Treatment of Hair Cycle Arrest in Intact Male Dogs

July 2014 in “ Veterinary dermatology ”

F Albanese, Eleonora Malerba, Francesca Abramo, Vincenzo Miragliotta, Federico Fracassi

deslorelin hair cycle arrest alopecia X intact male dogs neutered female dogs idiopathic hair cycle arrest castration

Studysummary This study found that deslorelin may promote hair regrowth in intact male dogs with hair cycle arrest, but had no effect on neutered females. Our plain-language summary of this paper — not a Tressless recommendation.

In a study evaluating the efficacy of a 4.7 mg deslorelin implant for treating hair cycle arrest (alopecia X) in dogs, 20 dogs with confirmed alopecia X were treated, including 16 intact males and 4 neutered females from various breeds. The results showed that 12 of the 16 intact male dogs (75%) experienced hair regrowth within 3 months, while no hair regrowth was observed in the neutered female dogs. The overall response rate to the treatment was 60%, with no adverse effects reported. The study concluded that deslorelin may be a viable treatment option for intact male dogs suffering from idiopathic hair cycle arrest and presents an alternative to current therapies and castration.

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Research cited in this study

9 / 9 results

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In this study, trilostane treatment led to complete hair re-growth in 85% of Pomeranians and all miniature poodles with alopecia X within 4 to 8 weeks.

Adrenal Steroid Hormone Concentrations in Dogs with Hair Cycle Arrest (Alopecia X) Before and During Treatment with Melatonin and Mitotane

research Adrenal Steroid Hormone Concentrations in Dogs with Hair Cycle Arrest (Alopecia X) Before and During Treatment with Melatonin and Mitotane

52 citations , October 2004 in “Veterinary dermatology”

This study found that 62% of neutered dogs with hair cycle arrest experienced partial to complete hair re-growth after melatonin treatment, but hair re-growth was not consistently linked to normal sex hormone levels.

research In Vitro Metabolism of Dehydroepiandrosterone and Testosterone by Canine Hair Follicle Cells

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This study found that canine dermal papilla cells and fibroblasts metabolize androgens differently than human hair follicle cells, indicating species-specific differences in androgen metabolism.

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