TLDR Trilostane effectively treated hair loss in Alaskan Malamutes with no adverse effects.
In a study from 2005, three Alaskan malamutes suffering from hair loss and elevated levels of 17-hydroxyprogesterone were treated with trilostane, a drug that inhibits 3 beta-hydroxysteroid dehydrogenase. The dogs received a dosage of 3.0 to 3.6 mg/kg per day orally, twice daily, for a period of 4 to 6 months. Their adrenal function was monitored with routine ACTH stimulation tests over 8 months. The treatment resulted in complete hair regrowth for all three dogs within 6 months, and no adverse effects from the trilostane were observed.
34 citations,
March 2003 in “Veterinary Dermatology” Most dogs with alopecia had higher than normal levels of certain hormones, but hair loss might not always be linked to these hormone changes.
149 citations,
June 2002 in “Veterinary record/The veterinary record” Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.
116 citations,
April 2002 in “American journal of veterinary research” Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.
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November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
12 citations,
January 2019 in “Journal of Endocrinology” Baicalin may help reduce excessive male hormone levels in PCOS.
