The Use of Trilostane for the Treatment of Alopecia X in Alaskan Malamutes
TLDR Trilostane effectively treated hair loss in Alaskan Malamutes with no adverse effects.
In a study from 2005, three Alaskan malamutes suffering from hair loss and elevated levels of 17-hydroxyprogesterone were treated with trilostane, a drug that inhibits 3 beta-hydroxysteroid dehydrogenase. The dogs received a dosage of 3.0 to 3.6 mg/kg per day orally, twice daily, for a period of 4 to 6 months. Their adrenal function was monitored with routine ACTH stimulation tests over 8 months. The treatment resulted in complete hair regrowth for all three dogs within 6 months, and no adverse effects from the trilostane were observed.
