TLDR Trilostane effectively treated hair loss in Alaskan Malamutes with no adverse effects.
In a study from 2005, three Alaskan malamutes suffering from hair loss and elevated levels of 17-hydroxyprogesterone were treated with trilostane, a drug that inhibits 3 beta-hydroxysteroid dehydrogenase. The dogs received a dosage of 3.0 to 3.6 mg/kg per day orally, twice daily, for a period of 4 to 6 months. Their adrenal function was monitored with routine ACTH stimulation tests over 8 months. The treatment resulted in complete hair regrowth for all three dogs within 6 months, and no adverse effects from the trilostane were observed.
34 citations
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March 2003 in “Veterinary Dermatology” Most dogs with alopecia had higher than normal levels of certain hormones, but hair loss might not always be linked to these hormone changes.
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June 2002 in “Veterinary record/The veterinary record” Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.
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April 2002 in “American journal of veterinary research” Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.
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November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
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January 2019 in “Journal of Endocrinology” Baicalin may help reduce excessive male hormone levels in PCOS.
