In Vitro Metabolism of Progesterone by Canine Hair Follicle Cells

    June 2005 in “ Veterinary Dermatology ”
    E. Bamberg, Amanda Aichinger, Gerda Wünsch
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    Studysummary In this study, dermal fibroblasts in the head of beagle dogs metabolized the highest amount of progesterone, primarily into cortisol, while dermal papilla cells mainly produced 5α-pregnane-3,20-dione and cortisol. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the in vitro metabolism of progesterone by canine hair follicle cells, specifically dermal papilla cells (DPC) and dermal fibroblasts (DFB), from four male, castrated beagle dogs. The cells were incubated with radioactive progesterone for 24 hours. The main metabolites identified in DFB were cortisol and 4-pregnene-11β-ol-3,20-dione, while in DPC, they were 5α-pregnane-3,20-dione and cortisol. The highest metabolism of progesterone was observed in DFB from the head. The study provided insights into the metabolic pathways of progesterone in canine hair follicle cells.
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