In Vitro Metabolism of Progesterone by Canine Hair Follicle Cells

June 2005 in “ Veterinary Dermatology ”

E. Bamberg, Amanda Aichinger, Gerda Wünsch

progesterone dermal papilla cells dermal fibroblasts hair follicles cortisol 5α-pregnane-3,20-dione 4-pregnene-11β-ol-3,20-dione

TLDR Canine hair follicle cells convert progesterone into various metabolites, mainly cortisol.

The study investigated the in vitro metabolism of progesterone by canine hair follicle cells, specifically dermal papilla cells (DPC) and dermal fibroblasts (DFB), from four male, castrated beagle dogs. The cells were incubated with radioactive progesterone for 24 hours. The main metabolites identified in DFB were cortisol and 4-pregnene-11β-ol-3,20-dione, while in DPC, they were 5α-pregnane-3,20-dione and cortisol. The highest metabolism of progesterone was observed in DFB from the head. The study provided insights into the metabolic pathways of progesterone in canine hair follicle cells.

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In Vitro Metabolism of Progesterone by Canine Hair Follicle Cells

Research cited in this study

research In Vitro Metabolism of Dehydroepiandrosterone and Testosterone by Canine Hair Follicle Cells

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