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Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors

research Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.

23 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

This study found that several synthesized pregnane derivatives exhibited significant inhibitory effects on testosterone conversion to dihydrotestosterone and reduced related androgenic parameters in multiple pharmacological models.

New Progesterone Esters as 5α-Reductase Inhibitors

research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.

22 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.

17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity

research 17α-Acetoxy-6-bromo-16β-methylpregna-4,6-diene-3,20-dione

December 1998 in “Acta Crystallographica Section C-crystal Structure Communications”

This study describes the molecular conformation and intermolecular interactions in the crystalline structure of the compound C24H31BrO4.

research Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

March 2025 in “Journal of Endocrinology and Metabolism”

This study found that while rat models treated with letrozole and dihydrotestosterone exhibit altered sterol, leukotriene, and steroid hormone profiles similar to human PCOS, significant differences remain.

research Effect of flutamide and two novel synthetic steroids on GABA, glutamine and some oxidative stress markers in rat brain and prostate

2 citations , January 2011 in “Andrologia”

This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.

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5 / 114 results

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

186 upvotes 1 year ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Is it me or are people losing their hair very young now?

in Finasteride/Dutasteride 143 upvotes 6 years ago

People notice more young individuals experiencing hair loss and discuss possible reasons, such as diet, hormones, and stress. Some treatments mentioned include finasteride, dutasteride, and minoxidil.

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