17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity

The document from 1998 reported on a new steroidal derivative with high antiandrogenic activity, identified as 17α-acetoxy-6-bromo-16β-methylpregna-4,6-diene-3,20-dione. The compound's structure includes three six-membered rings and one five-membered ring with specific conformations, and it was synthesized to explore treatments for androgen-mediated diseases such as hirsutism, acne, seborrhea, androgenic alopecia, precocious puberty, benign prostatic hyperplasia, and prostate cancer. The crystal structure is stabilized by van der Waals, C-H...Br, and C-H...O interactions, and was determined from ethyl acetate solution. The absolute configuration was deduced from known stereochemistry, and the crystallographic data were provided with normal bond lengths and angles. The study emphasized the compound's potential due to the side effects associated with current treatments for these conditions.