New Progesterone Esters as 5α-Reductase Inhibitors

January 2001 in “ Chemical & Pharmaceutical Bulletin ”

Marisa Cabeza, Ivonne Heuze, Eugene Bratoeff, E Murillo, Elena Ramírez, Alfonso Lira

progesterone esters 5α-reductase inhibitors androgenic alopecia 4-bromo-17α-(p-fluorobenzoyloxy)-4-pregnene-3,20-dione 4-bromo-17α-(p-bromobenzoyloxy)-4-pregnene-3,20-dione 4-bromo-17α-(p-chlorobenzoyloxy)-pregnene-3,20-dione 4-bromo-17α-(p-toluoyloxy)-4-pregnene-3,20-dione testosterone dihydrotestosterone DHT finasteride 5-alpha-reductase inhibitors androgenic alopecia testosterone DHT Propecia

Studysummary This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.

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