Androgenic and Anti-Androgenic Effects of Progesterone Derivatives with Different Halogens as Substituents at the C-6 Position

    June 1999 in “ Steroids ”
    Marisa Cabeza, E Gutiérrez, Renan Lyra Miranda … Elena Ramírez
    Studysummary This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.
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    Research cited in this study 2

    1. Use of Cyproterone Acetate in the Treatment of Acne, Hirsutism, and Virilism Journal of Steroid Biochemistry · 1975
    2. The Antiandrogenic Action of 4-Androsten-3-One-17β-Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ Endocrinology · 1973