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This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.

This study reported the development of new pyrazole-based MPC inhibitors that effectively inhibit mitochondrial pyruvate transport, showing potential as therapeutic candidates for conditions like metabolic dysfunction-associated steatohepatitis without activating PPARγ.

This study identified novel selective androgen receptor modulators with enhanced in vivo pharmacological activity through structure-activity relationship analysis in castrated rats.

A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.

This study developed a metal-free method for synthesizing sulfinimidate esters, showcasing their potential as versatile intermediates for enantioselective bond formation under mild conditions.