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Glossary Antiandrogenic Effects

inhibit male sex hormones like testosterone

Antiandrogenic effects refer to the actions of substances that inhibit the effects of androgens, which are male sex hormones like testosterone. These substances can block androgen receptors or reduce androgen production, and are often used in treatments for conditions like prostate cancer, androgenic alopecia (male-pattern baldness), and hirsutism (excessive hair growth in women).

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Research

5 / 1000+ results

research Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.

44 citations , March 2012 in “Fitoterapia”

In this study, germacrone from Curcuma aeruginosa showed anti-androgenic effects by inhibiting 5α-reductase, suggesting its potential as a lead compound for treating androgen-dependent disorders.

research Androgenic and anti-androgenic effects of progesterone derivatives with different halogens as substituents at the C-6 position

19 citations , June 1999 in “Steroids”

This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.

research Anti-Androgenic Effects of Spearmint Tea (Mentha Spicata)

January 2017 in “CommonKnowledge Research Repository (Pacific University Oregon)”

This review suggests spearmint tea may lower androgenic hormones in women with hirsutism and related symptoms, though longer treatment and follow-up may be needed for noticeable improvements.

research Anti-androgenetic effect of diphlorethohydroxycarmalol on testosterone-induced hair loss by inhibiting 5α-reductase and promoting Wnt/β-catenin signaling pathway in human dermal papilla cells

1 citations , February 2025 in “Toxicology in Vitro”

In this study, DPHC from the brown alga Ishige okamurae demonstrated potential to prevent androgenic alopecia by inhibiting hair loss and promoting hair growth through multiple cellular mechanisms.

research Anti-Androgen Effects of Extracts and Compounds fromGanoderma lucidum

20 citations , February 2009 in “Chemistry & Biodiversity”

This study found that Ganoderma lucidum extracts showed weak 5alpha-reductase inhibition but significantly inhibited prostate cell proliferation and testosterone-driven prostate growth in rats, suggesting potential as an ingredient for treating androgen-induced diseases.

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Community Join

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community I Get Side-Effects from Anti-Androgens

8 upvotes 6 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 2 years ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community Ranking of all the topical anti androgens in terms of effectivness?

5 upvotes 3 years ago

There is no reliable ranking for the effectiveness of topical anti-androgens like Fluridil, RU58841, and Pyrilutamide, with limited studies available. Some users suggest Pyrilutamide may be promising based on ongoing trials, while Fluridil combined with finasteride has shown positive results for some individuals.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 14 upvotes 1 year ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community Topical Anti Androgens detailed thread

6 upvotes 2 months ago

Users discuss the effectiveness of topical anti-androgens like RU58841, Pyri (KX826), and CB for hair loss. Some report maintenance and regrowth with Pyri, while others find limited success with RU58841 and switch to combinations like finasteride and minoxidil or minoxidil and dutasteride.

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Learn

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learn Spironolactone

Blood-pressure and diuretic drug with anti-androgen effects

learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn RU58841

Experimental topical anti-androgen sold as a research chemical

learn Valproic acid

Anti-seizure and mood-stabilising drug

learn Pyrilutamide

Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in men and women but is not approved for hair loss anywhere. Its sponsor reports one failed (2023) and one successful (2026) Phase III in men, none of it peer-reviewed; long-term safety is unknown, and anti-androgens are not considered appropriate in pregnancy.

learn HMI-115

HMI-115: Frequently Asked Questions About Hair Loss Treatment HMI-115 is an investigational anti-prolactin-receptor antibody being trialled for androgenetic alopecia. It is not approved anywhere; its hair-loss evidence is a 16-person Phase 1b announced only by press release, plus a completed 192-man Phase 2 in China whose results are not yet published.

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Clinics

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Experts

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Dermatologist
Andi Iryanti, M. Biomed
Indonesia

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Andi Iryanti, M. Biomed