TLDR Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.
In a 2012 study, researchers investigated the anti-androgenic effects of sesquiterpenes from Curcuma aeruginosa, with a focus on a compound named germacrone. Germacrone was found to be a potent inhibitor of 5α-reductase, the enzyme responsible for converting testosterone to dihydrotestosterone (DHT), which is linked to conditions like androgenic alopecia and benign prostatic hyperplasia. The compound effectively inhibited testosterone-induced growth in LNCaP cells and the flank gland of male Syrian hamsters, similar to the drug finasteride. However, germacrone was less effective against DHT-induced growth and did not bind to androgen receptors, suggesting its primary mechanism is through 5α-reductase inhibition. The study concluded that germacrone could be a potential treatment for androgen-dependent disorders, but the number of subjects involved in the study was not provided.
Cited in this study
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,
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January 2007 in “Biological & pharmaceutical bulletin” Black pepper leaf extract contains compounds that can block testosterone effects and promote hair growth.
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January 2001 in “Biological & Pharmaceutical Bulletin” The bark of Myrica rubra contains compounds that can block testosterone effects and might help prevent hair loss.
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January 2000 in “European Urology” Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.
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,
March 1996 in “Journal of the American Chemical Society” Finasteride effectively blocks enzyme causing male pattern baldness.
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,
July 2012 in “Fitoterapia” Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.
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,
May 2011 in “Cancer Biology & Therapy” Finasteride may improve prostate cancer treatment outcomes.