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GlossaryLNCaP cells

human prostate cancer cells used in research

LNCaP cells are a type of human prostate cancer cell line commonly used in scientific research. They are derived from a metastatic lesion of human prostatic adenocarcinoma and are used to study prostate cancer biology, including hormone responses and cancer progression.

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Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

45 citations, May 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

research Inhibitors of 5α-Reductase Type I in LNCaP Cells from the Roots of Angelica Koreana

22 citations, February 2002 in “Planta Medica”

Compounds from Angelica koreana roots, especially osthenol, could be effective for treating conditions like prostate disease and hair loss.

research Novel Type 1 5a-Reductase Inhibitors With Antiproliferative Potential On LNCaP Cells

June 2023 in “Oriental Journal of Chemistry/Oriental journal of chemistry”

New compounds may help treat prostate cancer by reducing cell growth.

Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth

research Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth

6 citations, January 2016 in “Evidence-based complementary and alternative medicine”

Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.

Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

research Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

56 citations, February 2006 in “American journal of physiology. Cell physiology”

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

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community Hair loss treatment rabbit hole [OC]

in Satire 317 upvotes 2 years ago

Hair loss treatments, ranging from topical minoxidil and finasteride to taking hormones such as estradiol or nandrolone, as well as a controversial suggestion of an orchiectomy. A hair system is also mentioned as an alternative solution.

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in Chat 6 upvotes 1 year ago

The conversation discusses maintaining hair regrowth using minoxidil and finasteride and whether using gt20029, which degrades androgen receptors, would affect this. Fluridil, a similar treatment, can disable over 90% of active androgen receptors.