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GlossaryLNCaP cells

human prostate cancer cells used in research

LNCaP cells are a type of human prostate cancer cell line commonly used in scientific research. They are derived from a metastatic lesion of human prostatic adenocarcinoma and are used to study prostate cancer biology, including hormone responses and cancer progression.

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research Inhibition of Proliferation of LNCaP Prostate Cells by Corni Fructus Extract Is Associated with a Decrease in the Expression of Benign Prostatic Hyperplasia-Causing Factors

1 citations , June 2021 in “Journal of Korean Medicine for Obesity Research”

Corni Fructus extract may help manage benign prostatic hyperplasia by reducing prostate cell growth and inflammation.

Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth

research Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth

6 citations , January 2016 in “Evidence-based complementary and alternative medicine”

Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.

research Synthesis of 17β-N-Arylcarbamoylandrost-4-en-3-one Derivatives and Their Anti-Proliferative Effect on Human Androgen-Sensitive LNCaP Cell Line

11 citations , June 2016 in “European Journal of Medicinal Chemistry”

Compounds 6f and 6g effectively stop prostate cancer cell growth without harming healthy cells.

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

research Inhibitors of 5α-Reductase Type I in LNCaP Cells from the Roots of Angelica Koreana

22 citations , February 2002 in “Planta Medica”

Compounds from Angelica koreana roots, especially osthenol, could be effective for treating conditions like prostate disease and hair loss.

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community Research: Minoxidil grows hair by suppressing androgen activity (DHT) in hair follicles.

in Minoxidil 43 upvotes 6 years ago

Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hair growth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community Hair loss treatment rabbit hole [OC]

in Satire 317 upvotes 3 years ago

Hair loss treatments, ranging from topical minoxidil and finasteride to taking hormones such as estradiol or nandrolone, as well as a controversial suggestion of an orchiectomy. A hair system is also mentioned as an alternative solution.

community Soo... i was pretty bored and was just brainstorming and ended up thinking about gt20029

in Chat 6 upvotes 3 years ago

The conversation discusses maintaining hair regrowth using minoxidil and finasteride and whether using gt20029, which degrades androgen receptors, would affect this. Fluridil, a similar treatment, can disable over 90% of active androgen receptors.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

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