The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor

May 2011 in “ Cancer Biology & Therapy ”

Yue Wu, Rishi Raj Chhipa, Hai-Tao Zhang, Clement Ip

finasteride androgen receptor AR LNCaP cells VCaP cells bicalutamide non-steroidal antiandrogen DHT androgen deprivation therapy Propecia Casodex dihydrotestosterone

TLDR Finasteride may improve prostate cancer treatment outcomes.

The study investigated the antiandrogenic effect of finasteride against a mutant androgen receptor (AR) in prostate cancer cells. The results showed that finasteride was able to inhibit the growth of LNCaP cells, but not VCaP cells. The study also compared the AR antagonistic effect of finasteride to that of bicalutamide, a non-steroidal antiandrogen, and found them to be comparable. The study suggests that finasteride could affect AR signaling beyond limiting the production of DHT, and additional studies are needed to investigate the susceptibility of various AR mutants to finasteride. The study concludes that finasteride could be beneficial in improving the outcome of androgen deprivation therapy for prostate cancer.

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Research cited in this study

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research Saturable Binding of Finasteride to Steroid 5α-Reductase as Determinant of Nonlinear Pharmacokinetics

16 citations, January 2010 in “Drug Metabolism and Pharmacokinetics”

Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.

research Androgen Biosynthetic Pathways in the Human Prostate

160 citations, April 2008 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

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research The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor

20 citations, May 2011 in “Cancer Biology & Therapy”

Finasteride may improve prostate cancer treatment outcomes.