The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor

    May 2011 in “ Cancer Biology & Therapy ”
    Yue Wu, Rishi Raj Chhipa, Hai-Tao Zhang, Clement Ip
    Studysummary This study found that finasteride decreased DHT-stimulated AR activity and cell growth in prostate cancer cells with mutant AR, but not in those with wild type AR.
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    Research cited in this study 3

    1. Saturable Binding of Finasteride to Steroid 5α-Reductase as Determinant of Nonlinear Pharmacokinetics Drug Metabolism and Pharmacokinetics · 2010
    2. Androgen Biosynthetic Pathways in the Human Prostate Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism · 2008
    3. Intermittent Use of Testosterone Inactivating Pharmaceuticals Using Finasteride Prolongs the Time Off Period The Journal of Urology · 2006

    Related research 1

    1. The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor Cancer Biology & Therapy · 2011