104 citations
,
December 2004 in “Journal of Neurochemistry” This study found that androgens, specifically DHT, induced neurite outgrowth in motor neurons by up-regulating the neuritin protein, with testosterone being less effective.
72 citations
,
January 2003 in “American Journal of Pathology” This study found that the co-activator CBP enhances the agonistic action of hydroxyflutamide on androgen receptors, suggesting a mechanism for therapy resistance in prostate cancer.
20 citations
,
May 2011 in “Cancer Biology & Therapy” This study found that finasteride decreased DHT-stimulated AR activity and cell growth in prostate cancer cells with mutant AR, but not in those with wild type AR.
16 citations
,
November 2023 in “Scientific Reports” This study developed a niosomal delivery system loaded with tretinoin and bicalutamide, optimized for follicular targeting in acne management, showing promising accumulation in hair follicles in animal models.
12 citations
,
December 2012 in “Current Drug Targets” The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.