Anti-Androgenetic Effect of Diphlorethohydroxycarmalol on Testosterone-Induced Hair Loss by Inhibiting 5α-Reductase and Promoting Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells

    February 2025 in “ Toxicology in Vitro
    Seung Tae Im, Haeun Mun, Nalae Kang, Soo-Jin Heo, Seung‐Hong Lee
    TLDR Diphlorethohydroxycarmalol may help treat hair loss better than current medications.
    The study explores the potential of diphlorethohydroxycarmalol (DPHC), derived from the brown alga Ishige okamurae, in treating testosterone-induced hair loss. DPHC effectively inhibits 5α-reductase, outperforming finasteride, a standard treatment for androgenic alopecia, and enhances the Wnt/β-catenin signaling pathway, essential for hair growth. These results indicate that DPHC could be a natural alternative for managing androgenic alopecia, potentially offering a new treatment option with fewer side effects compared to existing medications.
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