Anti-Androgenetic Effect of Diphlorethohydroxycarmalol on Testosterone-Induced Hair Loss by Inhibiting 5α-Reductase and Promoting Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells

    February 2025 in “ Toxicology in Vitro ”
    Seung Tae Im, Haeun Mun, Nalae Kang … Seung‐Hong Lee
    Studysummary In this study, DPHC from the brown alga Ishige okamurae demonstrated potential to prevent androgenic alopecia by inhibiting hair loss and promoting hair growth through multiple cellular mechanisms.
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    Research cited in this study 36

    1. Effects of Camellia Oleifera Seed Shell Polyphenols and 1,3,6-Tri-O-Galloylglucose on Androgenic Alopecia via Inhibiting 5α-Reductase and Regulating Wnt/β-Catenin Pathway Fitoterapia · 2024
    2. Progress on the Mechanism of Natural Products Alleviating Androgenetic Alopecia European Journal of Medicinal Chemistry · 2023
    3. Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway Nutrients · 2023
    4. Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells Molecules · 2022
    5. Modulation of Hair Growth Promoting Effect by Natural Products Pharmaceutics · 2021
    6. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    7. Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth Frontiers in Cell and Developmental Biology · 2021
    8. Physcion, a Novel Inhibitor of 5α-Reductase That Promotes Hair Growth In Vitro and In Vivo Archives of Dermatological Research · 2021
    9. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    10. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    11. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    12. Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway International Journal of Molecular Sciences · 2020
    13. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
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    15. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
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    17. Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness Nature Communications · 2018
    18. Activating Wnt/β-Catenin Signaling Pathway for Disease Therapy: Challenges and Opportunities Pharmacology & Therapeutics · 2018
    19. Medicinal Plants for the Treatment of Hair Loss and the Suggested Mechanisms Current Pharmaceutical Design · 2018
    20. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    21. Undariopsis Peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways Marine Drugs · 2017
    22. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    23. Androgenetic Alopecia: A Review Endocrine · 2017
    24. Multi-Therapies in Androgenetic Alopecia: Review and Clinical Experiences Dermatologic Therapy · 2016
    25. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    26. The Basic Science of Hair Biology Dermatologic Clinics · 2012
    27. Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells Journal of Dermatological Science · 2011
    28. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    29. Alopecia: Evaluation and Treatment Clinical, Cosmetic and Investigational Dermatology · 2011
    30. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    31. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    32. Male Pattern Androgenetic Alopecia in an Indian Context: A Perspective Study Journal of The European Academy of Dermatology and Venereology · 2007
    33. Androgen Action on Human Skin – From Basic Research to Clinical Significance Experimental dermatology · 2004
    34. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    35. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    36. Finasteride, a Type 2 5α-Reductase Inhibitor, in the Treatment of Men with Androgenetic Alopecia Expert Opinion on Investigational Drugs · 1999

    Related research 4

    1. Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review Brazilian Journal of Hair Health · 2024
    2. 5 Alpha-Reductase and Finasteride in Pattern Alopecia and Acne PubMed · 2004
    3. Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men The Journal of Clinical Endocrinology and Metabolism · 1996
    4. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992