Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway

    January 2023 in “ Nutrients ”
    Caibing Wang, Kai Zang, Zexin Tang, Ting Yang, Xiyun Ye, Yongyan Dang
    TLDR Hordenine may help hair grow by activating a specific cell growth pathway.
    The study found that Hordenine, a natural compound from germinated barley, promotes hair regrowth by activating the Wnt/β-catenin signaling pathway. It significantly increased the proliferation and activity of dermal papilla cells (DPCs) and promoted hair shaft elongation in both in vitro and in vivo models. The effects were confirmed by upregulation of key markers and reversed by a Wnt/β-catenin inhibitor, indicating the pathway's crucial role. These findings suggest Hordenine as a promising, low-toxicity treatment for alopecia.
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