Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

March 2022 in “ Journal of Biomedical Science ”

Young Hyun Jung, Chang Woo Chae, Gee Euhn Choi, Him Cha Shin, Jae Ryong Lim, Han Seung Chang, Joonmo Park, Ji Hyeon Cho, Mo Ran Park, Hyun Jik Lee, Ho Jae Han

cyanidin 3-O-arabinoside C3A dihydrotestosterone DHT dermal papilla cell DPC androgenetic alopecia AGA mitochondrial reactive oxygen species p38 voltage-dependent anion channel 1 VDAC1 mitochondria-associated ER membrane MAM hair follicle stem cell proliferation mitochondrial ROS

TLDR Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.

The study investigated the effects of cyanidin 3-O-arabinoside (C3A) on dihydrotestosterone (DHT)-induced dermal papilla cell (DPC) senescence, a condition linked to androgenetic alopecia (AGA), a common form of hair loss. The researchers found that C3A decreased DHT-induced mitochondrial reactive oxygen species accumulation in DPCs and reversed DHT-induced DPC senescence. C3A also prevented excessive mitochondrial calcium accumulation and inhibited p38-mediated voltage-dependent anion channel 1 (VDAC1) expression, which contributes to mitochondria-associated ER membrane (MAM) formation and calcium transfer. In AGA mice models, C3A restored DHT-induced hair growth deceleration and activated hair follicle stem cell proliferation. The study concludes that C3A is a promising natural compound for AGA treatments against DHT-induced DPC senescence by reducing MAM formation and mitochondrial dysfunction.

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