Effects of Camellia Oleifera Seed Shell Polyphenols and 1,3,6-Tri-O-Galloylglucose on Androgenic Alopecia via Inhibiting 5α-Reductase and Regulating Wnt/β-Catenin Pathway

    July 2024 in “ Fitoterapia ”
    Qi Ru, Kun Huang, Robert K. Yu, Xiaojiang Wu, Jianfu Shen
    TLDR Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose can help treat hair loss by reducing certain hormones and promoting hair growth.
    The study explored the impact of Camellia oleifera seed shell polyphenols (CSSP) and 1,3,6-tri-O-galloylglucose (TGG) on androgenic alopecia (AGA) in mice. Results showed that CSSP and TGG alleviated alopecia by inhibiting 5α-reductase and regulating the Wnt/β-catenin pathway, leading to reduced androgen levels and prolonged hair growth. These findings indicate that CSSP and TGG could be promising treatments for AGA by targeting these specific pathways.
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