Effects of Camellia Oleifera Seed Shell Polyphenols and 1,3,6-Tri-O-Galloylglucose on Androgenic Alopecia via Inhibiting 5α-Reductase and Regulating Wnt/β-Catenin Pathway

July 2024 in “ Fitoterapia ”

Qi Ru, Kun Huang, Robert K. Yu, Xiaojiang Wu, Jianfu Shen

Camellia oleifera seed shell polyphenols 1,3,6-tri-O-galloylglucose androgenetic alopecia 5α-reductase Wnt/β-catenin pathway molecular docking DHT SRD5A2-AR receptor signaling pathway CSSP TGG AGA dihydrotestosterone 5-alpha-reductase Wnt pathway

Studysummary This study found that Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose improved androgenetic alopecia symptoms in mice by reducing DHT levels and activating specific hair growth pathways. Our plain-language summary of this paper — not a Tressless recommendation.

The study explored the impact of Camellia oleifera seed shell polyphenols (CSSP) and 1,3,6-tri-O-galloylglucose (TGG) on androgenic alopecia (AGA) in mice. Results showed that CSSP and TGG alleviated alopecia by inhibiting 5α-reductase and regulating the Wnt/β-catenin pathway, leading to reduced androgen levels and prolonged hair growth. These findings indicate that CSSP and TGG could be promising treatments for AGA by targeting these specific pathways.

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