Effects of Camellia Oleifera Seed Shell Polyphenols and 1,3,6-Tri-O-Galloylglucose on Androgenic Alopecia via Inhibiting 5α-Reductase and Regulating Wnt/β-Catenin Pathway

July 2024 in “ Fitoterapia ”

Qi Ru, Kun Huang, Robert K. Yu, Xiaojiang Wu, Jianfu Shen

Camellia oleifera seed shell polyphenols 1,3,6-tri-O-galloylglucose androgenetic alopecia 5α-reductase Wnt/β-catenin pathway molecular docking DHT SRD5A2-AR receptor signaling pathway CSSP TGG AGA dihydrotestosterone 5-alpha-reductase Wnt pathway

TLDR Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose can help treat hair loss by reducing certain hormones and promoting hair growth.

This study investigated the effects of Camellia oleifera seed shell polyphenols (CSSP) and 1,3,6-tri-O-galloylglucose (TGG) on androgenetic alopecia (AGA) by inhibiting 5α-reductase and regulating the Wnt/β-catenin pathway. Using molecular docking and a mouse model of DHT-induced AGA, researchers found that CSSP and TGG alleviated alopecia symptoms, reduced DHT and androgen levels, and extended hair growth duration. The findings suggest that CSSP and TGG can improve AGA by targeting the SRD5A2-AR receptor signaling pathway and activating the Wnt/β-catenin pathway, offering new insights into AGA treatment mechanisms.

View this study on sciencedirect.com →

Discuss this study in the Community →

9 / 9 results

research Side Effects Related to 5 Alpha-Reductase Inhibitor Treatment of Hair Loss in Women: A Review

6 citations, April 2016 in “PubMed”

The review found that women using hair loss drugs like finasteride and dutasteride rarely reported sexual side effects.

research Finasteride in the Treatment of Female Androgenic Alopecia

November 2014 in “PharmaTutor”

Finasteride may help postmenopausal women with hair loss but is not effective for all and should be used cautiously in premenopausal women.

research Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss

12 citations, July 2004 in “PubMed”

Finasteride, especially in a 1mg dose, effectively slows hair loss and improves hair growth in Japanese men with male pattern hair loss.

research Finasteride in the Treatment of Androgenetic Alopecia

62 citations, April 2004 in “Expert Opinion on Pharmacotherapy”

Finasteride effectively treats male pattern baldness, improving hair growth and density.

research Hair Loss in Women with Hyperandrogenism: Four Cases Responding to Finasteride

92 citations, November 2002 in “Journal of The American Academy of Dermatology”

Finasteride improves hair loss in women with hyperandrogenism.

research Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Treatment with Finasteride, 1 mg, Daily

66 citations, April 2002 in “Journal of The American Academy of Dermatology”

Finasteride increases hair weight and count in men with hair loss.

research Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies

10 citations, June 2001 in “PubMed”

Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.

research Current Management of Androgenetic Alopecia in Men

4 citations, December 1999 in “PubMed”

Minoxidil and finasteride are promising drugs that can prevent hair loss and promote new growth in people with common hair loss condition.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations, October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.