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    GlossarySystemic Antiandrogens

    medications that reduce male hormone effects body-wide

    Systemic antiandrogens are medications that reduce the effects of androgens (male hormones) throughout the entire body. They are commonly used to treat conditions like androgenic alopecia (hair loss), prostate cancer, and severe acne by blocking androgen receptors or inhibiting androgen production. These therapies can be crucial for managing hormone-related disorders and are often referred to as systemic anti-androgen therapy.

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      learn Pyrilutamide

      highly targeted anti-androgen that might have minimal systemic effects

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn Dutasteride

      Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

      learn Minoxidil

      An essential vasodilator with some anti-androgenic effects, has excellent safety record

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      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  35 upvotes 5 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Insane MTF recovery 18 months blocking androgens

      in Progress Pictures  145 upvotes 1 year ago
      Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

      community Methods Of Staying Safe On Ru58841 - My 2 Cents

      in Research/Science  13 upvotes 2 months ago
      RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.